EC Dental Science

Myoepithelial carcinoma of salivary gland emerges as a carcinoma constituted of myoepithelial cells in entirety or demonstrating an almost comprehensive population of myoepithelial cells. Myoepithelial carcinoma of salivary gland exhibits an infiltrative pattern of tumour growth.

Tumefaction may arise de novo or as myoepithelial carcinoma ex pleomorphic adenoma. Generally, myoepithelial carcinoma appears as an under-reported entity. Additionally, the terminology of malignant myoepithelioma appears debatable and non advocated.

Comprehensively composed of myoepithelial cells, myoepithelial carcinoma of salivary gland is devoid of a contemporary, well defined grading system.

Salivary gland myoepithelial carcinoma is subcategorized as myoepithelial carcinoma de novo or myoepithelial carcinoma ex pleomorphic adenoma. An estimated > 50% neoplasms exhibit PLAG1 genetic fusion.

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3. Luo Y. “Myoepithelial carcinoma of major salivary glands: Analysis of population-based clinicopathologic and prognostic features”. Translational Oncology 20 (2022): 101410.
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6. Image 1 Courtesy: Research gate.
7. Image 2 Courtesy: Medscape.