EC Dental Science

Current World Health Organization (WHO) classification of salivary gland tumours comprises of neoplasms depicting characteristic genetic fusions which engender novel and contemporary neoplastic entities.

Micro-secretory adenocarcinoma of salivary gland (MSA) emerges as a distinct, contemporary, unique neoplasm with significant, consistent clinical and genetic features and an indolent clinical course. Initially scripted in 2019, the low grade tumefaction demonstrates characteristic histological features, immuno-phenotypic profile and repetitive genetic fusion MEF2C-SS18.

However, the recently described neoplasm is devoid of comprehensive, specific clinical or pathological spectrum wherein cogent biological behavior remains undocumented.

Immunohistochemistry for S100 protein, SOX10, p63, p40, smooth muscle actin (SMA), calponin and mammaglobin along with molecular assay comprised of targeted RNA sequencing, SS18 break apart fluorescent in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR) for discerning MEF2C-SS18 genetic fusion may be beneficially adopted for appropriate tumor discernment.

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5. Rooper LM. “Emerging entities in salivary pathology a practical review of sclerosing microcystic adenocarcinoma, microsecretory adenocarcinoma, and secretory myoepithelial carcinoma”. Surgical Pathology Clinics 1 (2021): 137-150.
6. Image 1 Courtesy: Ingenta connect.
7. Image 2 Courtesy: Research gate.