EC Dental Science

Basal cell adenocarcinoma of salivary glands emerges as a primary, low grade carcinoma of salivary glands. Basal cell adenocarcinoma is an exceptionally discerned primary tumour of salivary glands configuring < 2% of malignant salivary gland neoplasms. The low grade, malignant salivary gland neoplasm is commonly confined to parotid gland. Minor salivary glands or diverse major salivary glands are uncommonly incriminated. The biphasic tumefaction delineates a dual cell population comprised of basal cells and ductal epithelial cells.

Morphologically, tumefaction appears reminiscent of basal cell adenoma although neoplasm manifests an invasive pattern of tumour progression. Cogent tumour discernment is contingent to demonstration of dual cell population constituted of centric ductal cells and ab-luminal basal cells delineating peripheral palisading of nuclei. Foci of squamous cellular or sebaceous differentiation may be enunciated.

Precise therapeutic strategy emerges as surgical extermination of the neoplasm with achievement of surgical tumour free tissue perimeter.

1. Rito M., et al. “Basal Cell Adenoma and Basal Cell Adenocarcinoma: a 50-year Experience From a Single Institution”. Head and Neck Pathology 4 (2022): 1157-1166.
2. Robinson RA. “Basal Cell Adenoma and Basal Cell Adenocarcinoma”. Surgical Pathology Clinics 1 (2021): 25-42.
3. Oyama Y., et al. “Difference in transducin-like enhancer of split 1 protein expression between basal cell adenomas and basal cell adenocarcinomas - an immunohistochemical study”. Diagnostic Pathology 1 (2018): 48.
4. Skálová A., et al. “Update from the 5^th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands”. Head and Neck Pathology 1 (2022): 40-53.
5. Andreasen S., et al. “An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome”. APMIS5 (2019): 240-264.
6. Image 1 Courtesy: Libre pathology.
7. Image 2 Courtesy: Wikimedia commons