EC Dental Science

NUT carcinoma of sinonasal tract is a carcinoma demonstrating characteristic genomic translocations confined to NUT gene. Neoplasm is engendered by genetic translocations within the NUT gene situated upon chromosome 15q14 and a commonly enunciated BRD4 gene confined to chromosome 19p13. Tumefaction frequently delineates foci of squamous differentiation.

 Morphologically, neoplasm is configured of primitive round cells admixed with zones of abrupt keratinization. Upon immunohistochemistry, speckled nuclear immune reactivity of NUT1 is exemplified, a feature which may be employed as a sensitive and specific indicator of neoplastic emergence. The malignant neoplasm enunciates an aggressive clinical course and median survival of < 1 year.

1. Wang L., et al. “Sinonasal NUT carcinoma: A retrospective case series from a single institution”. Frontiers in Surgery 10 (2023): 1098704.
2. Everton Assunção Ribeiro da Costa R., et al. “A case of metastatic NUT carcinoma of the nasal cavity”. Oral Oncology (2023).
3. Zhang K., et al. “A sinonasal NUT midline carcinoma in an 84-year-old man undergoing radiation and proton therapy”. Clinical Case Reports7 (2023): e7262.
4. Wartenberg M., et al. “Differentiated Papillary NUT Carcinoma: An Unexpected, Deceptively Bland Presentation of a Sinonasal Carcinoma”. Head and Neck Pathology (2023).
5. Fu S., et al. “The whole treatment process and thinking of a patient with NUT carcinoma of the parotid gland: a case report”. Frontiers in Oncology 13 (2023): 1094770.
6. Image 1 Courtesy: Wikipedia.
7. Image 2 Courtesy: Pathology outlines.