EC Dental Science

Salivary duct carcinoma represents as a malignant, high grade salivary gland neoplasm which morphologically simulates invasive ductal carcinoma of breast and manifests an in situ and invasive component. Salivary duct carcinoma was initially scripted by Kleinsasser in 1968.

As a malignant, high grade neoplasm of salivary glands delineating histological features akin to invasive ductal carcinoma of breast, tumefaction is predominantly (> 90%) immune reactive to luminal androgen receptors (AR). Besides, foci of in situ duct carcinoma frequently display comedo necrosis.

Additionally designated as high grade ductal carcinoma, salivary duct carcinoma represents ~10% of malignant salivary gland neoplasms. Tumefaction is accompanied by inferior prognostic outcomes.

Salivary duct carcinoma commonly incriminates subjects within 6^th decade to 7^th decade with mean age of disease emergence at 67.4 years. Nevertheless, neoplasm may arise within a comprehensive age range of 33 years to 92 years. A male predilection is encountered with male to female proportion of ~2.4:1 [1,2].

Salivary duct carcinoma preponderantly incriminates parotid gland. Besides, submandibular gland or minor salivary glands may be implicated.

1. Liu F., et al. “Comprehensive diagnosis and treatment of ductal carcinoma of the submandibular gland: case report and literature review”. International Journal of Clinical and Experimental Pathology 3 (2023): 67-75.
2. Young A and Okuyemi OT. “Malignant Salivary Gland Tumors”. Stat Pearls International. Treasure Island, Florida (2023).
3. Bou Zerdan M., et al. “Molecular Targets in Salivary Gland Cancers: A Comprehensive Genomic Analysis of 118 Mucoepidermoid Carcinoma Tumors”. Biomedicines 2 (2023): 519.
4. Laughlin BS., et al. “Clinicopathologic Factors and Their Association with Outcomes of Salivary Duct Carcinoma: A Multicenter Experience”. Advances in Radiation Oncology 4 (2023): 101204.
5. Cunha JL., et al. “Salivary gland tumors: A 13-year clinicopathologic retrospective study in a Brazilian northeast population”. Journal of Clinical and Experimental Dentistry 2 (2023): e88-e95.
6. Image 1 Courtesy: Wikipedia
7. Image 2 Courtesy: My pathology report.