EC Dental Science

Keywords: Nanopharmaceuticals; Artificial Intelligence; Drug Delivery; Oral Surgery; Dental Materials; Targeted Therapy; 3-D Printing; Machine Learning; Controlled Release; Nanoparticles

Pharmaceuticals play a crucial role in modern or contemporary dentistry and oral surgery, helping to control and manage pain, reduce inflammation/edema, prevent infection, and facilitate oral and dental interventional procedures. Indeed, some common pharmaceuticals used in dentistry include local anesthetics, analgesics, anti-inflammatory drugs, antibiotics, and sedatives. Herein, nano-pharmaceutics is a rapidly developing sub-field of pharmacology, pharmaceuticals, and drug delivery systems that, basically, utilize nanoparticles (nanocapsules, nanospheres, amongst others) to target specific cells and/or tissues.

1. Bashir U and Alhadainy HA. “Dental pharmacology: A concise review for dental practitioners”. Journal of International Oral Health5 (2017): 229-234.
2. Tripathi KD. “Essentials of medical pharmacology”. Jaypee Brothers Medical Publishers (2013).
3. Newman MG., et al. “Carranza's clinical periodontology”. Elsevier Health Sciences (2015).
4. Fouad AF and Barry J. “Medications Used in Dentistry”. In Pharmacology and Therapeutics for Dentistry (2018): 104-114.
5. Al-Dabbagh NM and Al-Hayali NN. “Dental Pain: Current Concepts”. In Orofacial Pain Springer, Cham (2019): 261-277.
6. Haas DA. “Local anesthetic pharmacology and administration”. Anesthesia Progress2 (2014): 90-102.
7. Malamed SF. “Handbook of local anesthesia”. Elsevier Health Sciences (2019).
8. Dionne RA. “Pharmacologic management of pain for oral and maxillofacial surgeons”. Oral and Maxillofacial Surgery Clinics3 (2018): 307-317.
9. Lohr NL. “Pharmacology for oral health care providers”. Pearson (2017).
10. Herrera D., et al. “Differences in antimicrobial activity of four commercial 0.12% chlorhexidine mouthrinse formulations: an in vitro contact test and salivary bacterial counts study”. Journal of Clinical Periodontology11 (2000): 823-827.
11. Roberts GJ. “Dentistry and antibiotics: prescribing practices of dental practitioners”. British Dental Journal12 (2000): 647-650.
12. Becker DE and Rosenberg M. “Nitrous oxide and the inhalation anesthetics”. Anesthesia Progress2 (2013): 58-68.
13. American Dental Association. Antibiotic use in dentistry (2018).
14. American Dental Association. Drug interactions (2018).
15. Malamed SF. “Sedation: a guide to patient management”. Elsevier Health Sciences (2020).
16. Anselmo AC and Mitragotri S. “Nanoparticles in the clinic: An update”. Bioengineering and Translational Medicine3 (2019): e10143.
17. Davis ME., et al. “Nanoparticle therapeutics: an emerging treatment modality for cancer”. Nature Reviews Drug Discovery9 (2008): 771-782.
18. De Jong WH and Borm PJ. “Drug delivery and nanoparticles: applications and hazards”. International Journal of Nanomedicine2 (2008): 133-149.
19. Nanotechnology: A Report of the U.S. Food and Drug Administration Nanotechnology Task Force. U.S. Food and Drug Administration (2007).
20. Farokhzad OC and Langer R. “Nanomedicine: developing smarter therapeutic and diagnostic modalities”. Advanced Drug Delivery Reviews14 (2006): 1456-1459.
21. Gupta AK and Gupta M. “Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications”. Biomaterials18 (2005): 3995-4021.
22. Huang X., et al. “Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy”. Nanomedicine5 (2007): 681-693.
23. Kabanov AV and Vinogradov SV. “Nanogels as pharmaceutical carriers: finite networks of infinite capabilities”. Angewandte Chemie International Edition in English30 (2009): 5418-5429.
24. Khlebtsov N and Dykman L. “Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies”. Chemical Society Reviews3 (2011): 1647-1671.
25. Kim BYS., et al. “Nanomedicine”. The New England Journal of Medicine25 (2010): 2434-2443.
26. Labouta HI and Schneider M. “Interaction of nanoparticles with skin barrier lipids: physicochemical and thermodynamic considerations”. Skin Pharmacology and Physiology5 (2017): 246-260.
27. Langer R and Folkman J. “Polymers for the sustained release of proteins and other macromolecules”. Nature5580 (1976): 797-800.
28. Li SD and Huang L. “Pharmacokinetics and biodistribution of nanoparticles”. Molecular Pharmaceutics4 (2008): 496-504.
29. Mitragotri S. “Stay in the (nano) zone: the myth of a general-purpose delivery technology”. ACS Nano1 (2014): 3-7.
30. Van Nostrum CF. “Polymeric micelles to deliver photosensitizers for photodynamic therapy”. Advanced Drug Delivery Reviews1 (2004): 9-16.
31. Bhatia SK and Dube K. “Nanotechnology in dentistry: a review”. International Journal of Health Sciences2 (2019): 51-57.
32. Zhang Z., et al. “3D printing drug delivery devices for the mouth”. Journal of Controlled Release 305 (2019): 180-196.
33. Goyanes A., et al. “Fused-filament 3D printing (3DP) for fabrication of tablets”. International Journal of Pharmaceutics1-2 (2014): 88-92.
34. Bose S., et al. “Bone tissue engineering using 3D printing”. Materials Today12 (2013): 496-504.
35. Lee JH., et al. “Nanotopography-guided tissue engineering and regenerative medicine”. Advanced Drug Delivery Reviews4 (2014): 536-558.
36. Patel H., et al. “Hybrid 3D printing in dentistry”. Journal of Indian Prosthodontic Society4 (2019): 295-299.
37. Alharbi N., et al. “Additive manufacturing techniques in prosthodontics: Where do we currently stand? A critical review”. International Journal of Prosthodontics5 (2017): 474-484.
38. Zandinejad A and Van Noort R. “Hybrid layered manufacturing: A rapid prototyping system based on fused deposition modeling and stereolithography”. Journal of Prosthetic Dentistry3 (2006): 139-143.
39. Kruth JP., et al. “Consolidation phenomena in laser and powder-bed based layered manufacturing”. CIRP Annals2 (2007): 730-759.
40. Lee H and Cho DW. “One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology”. Lab on a Chip14 (2016): 2618-2625.
41. Ahmad T., et al. “Artificial intelligence in dentistry: A review”. Journal of Artificial Intelligence in Dentistry1 (2019): 3-8.
42. Joda T., et al. “Digital dentistry: A review of the state of the art”. Swiss Dental Journal9 (2018): 652-662.
43. Estai M and Kruger E. “Artificial intelligence in dentistry: current applications and future perspectives”. Quintessence International8 (2018): 677-688.
44. Zhang X., et al. “Artificial intelligence in medical devices: Opportunities, challenges, and future prospects”. Journal of Medical Systems7 (2019): 166.
45. Khorrami F., et al. “A comprehensive review of artificial intelligence applications in dentistry”. Journal of Clinical and Experimental Dentistry1 (2020): e89-e96.
46. Hasselqvist M., et al. “Application of artificial intelligence in dentistry: A review of the literature”. Journal of Oral Science1 (2021): 1-7.
47. Kim EK and Lee JH. “The current status and future of dental implant technology”. Journal of Biomedical Research6 (2018): 401-410.
48. Li H., et al. “Artificial intelligence in medical devices: A review”. Journal of Biomedical Informatics 115 (2021): 103696.
49. Samset E and Kaspersen JH. “Artificial intelligence in healthcare: The hype, the hope, the promise, the peril”. IEEE Pulse5 (2019): 6-9.
50. Yoon DY., et al. “Artificial intelligence in medical imaging: Current status and future prospects”. Korean Journal of Radiology4 (2019): 629-640.
51. Bhandari S. “Artificial intelligence in dentistry”. Journal of Dental Research and Review1 (2020): 6-10.
52. Joda T., et al. “The emerging role of artificial intelligence in dentistry: A review”. Dentistry Journal1 (2021): 11.
53. Rajkomar A., et al. “Machine learning in medicine”. New England Journal of Medicine14 (2019): 1347-1358.
54. Swain SK., et al. “A review of artificial intelligence in dental and oral healthcare”. Health and Technology5 (2021): 1085-1094.
55. Chen M., et al. “Applications and progress of artificial intelligence in dentistry”. Current Medical Imaging Reviews5 (2020): 466-471.
56. Al-Dasuqi K., et al. “The application of artificial intelligence in dentistry”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology4 (2021): 437-444.
57. Rana V., et al. “Artificial intelligence in dentistry: A review”. Journal of Dentistry and Oral Health1 (2020): 9-14.
58. Hassabis D. “AlphaGo Zero: Starting from scratch”. Deep Mind Blog (2017).
59. Akkaya I., et al. “A review of the application of artificial intelligence in dentistry”. International Journal of Advanced Science and Technology5 (2021): 1908-1916.
60. Chowdhry A., et al. “Applications of artificial intelligence in dentistry”. Journal of Clinical and Diagnostic Research3 (2021): ZE12-ZE15.
61. Dursteler R., et al. “The potential of artificial intelligence in dental education: A review”. European Journal of Dental Education1 (2021): 1-10.
62. Yu L and Guan X. “The application of artificial intelligence in dentistry: A review”. Frontiers in Medicine 7 (2020): 627.
63. Patil SS and Patil SR. “Artificial intelligence in dentistry: The future is here”. Journal of Interdisciplinary Dentistry1 (2020): 32-36.
64. Schneider M and De Faria Vasconcelos K. “Artificial intelligence and its applications in dentistry: A narrative review”. Journal of Dental Sciences3 (2021): 753-761.
65. Joshi H and Ma Y. “Artificial intelligence in healthcare: Past, present and future”. The American Journal of Managed Care10 (2018): 393-396.