EC Dental Science

Research Article Volume 25 Issue 9 - 2026

Regenerative Potential of Platelet-Rich Plasma-Enriched Autograft and Xenograft in Peri-Implant Deficient Sites: A Clinical and Radiological Study

Komal S Sharma1, Chetan Sharma2, Dipti Singh3, Kunal Pathak4, Surbhi Singh5, Kumar Kartikey5, Reena Yadav6, Naushi Ali Naushad7, Aviral Singh7, Manoj Maurya7 and Sudhanshu Agrawal8*

1Associate Professor, Department of Periodontology, Chandra Dental College and Hospital, Safedabad, Barabanki, UP, India
2Assistant Professor, Department of Oral Pathology, Chandra Dental College and Hospital, Safedabad, Barabanki, UP, India
3Professor and HOD, Department of Oral Medicine and Radiology, Chandra Dental College and Hospital, Safedabad, Barabanki, UP, India
4P.G. Student, Department of Periodontology, Rama Dental College Hospital and Research Centre, Kanpur, UP, India
5Assistant Professor, Department of Periodontology, Chandra Dental College and Hospital, Safedabad, Barabanki, UP, India
6Lecturer, Purvanchal Institute of Dental Sciences, Gorakhpur, UP, India
7Dental Student, Chandra Dental College and Hospital, Safedabad, Barabanki, UP, India
8Professor and HOD, Department of Periodontology, Chandra Dental College and Hospital, Safedabad, Barabanki, UP, India

*Corresponding Author: Sudhanshu Agrawal, Professor and HOD, Department of Periodontology, Chandra Dental College and Hospital, Safedabad, Barabanki, UP, India. E-mail ID: drsudhanshu_bds@hotmail.com.
Received: July 28, 2026; Published: September 02, 2026



Background: Platelet-rich plasma (PRP) is an autologous concentrate rich in growth factors that may enhance bone regeneration and healing around dental implants. This study evaluated the efficacy of PRP combined with autograft and xenograft in peri-implant deficient sites.

Methods: Ten patients with peri-implant bone deficiencies were treated with a PRP-enriched autograft-xenograft mixture. Clinical parameters including pain, swelling, wound dehiscence, infection, and implant mobility were assessed. Radiological evaluation was performed using digital tomograms preoperatively and at 3 months postoperatively. Area-wise measurements were analyzed using SYSTAT (Sigma Scan Pro 5) software.

Results: Mild postoperative pain and swelling were observed in a few cases, no implant mobility or infection was observed after 3 months. Radiological assessment demonstrated a significant increase in bone area measurements at grafted sites compared with baseline values.

Conclusion: PRP-enriched autograft and xenograft demonstrated favorable clinical healing and enhanced bone regeneration in peri-implant deficient areas. The combination appears to be a promising adjunct for improving early peri-implant bone healing.

Keywords: Platelet-Rich Plasma; Autograft; Xenograft; Bone Regeneration; Dental Implants; Peri-Implant Defects

  1. Carl Misch. “Text book of Implant dentistry”. Elsevier Mosby (2005).
  2. Robert E Marx and Arun K Garg. “Book of dental and craniofacial applications of platelet rich plasma”. Quintessence publishing Co, Inc (2005).
  3. Robert E Marx and Eric R Carlson. “Platelet-rich plasma. Growth factor enhancement for bone grafts”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology and Endodontics 6 (1998): 638-646.
  4. Earl G Freymiller and Tara L Aghaloo. “Platelet-rich plasma: Ready or not?” Journal of Oral and Maxillofacial Surgery 62 (2004): 484-488.
  5. Abhijit Varghese. Book of Tissue Engineering CVG Books (2007).
  6. Abad Rashmi and Gawande Pushkar. “Treatment of a large peri apical lesion with combination of platelet-rich plasma and hydroxy apatite: A case report”. JPFA 21 (2007).
  7. Per-Ingvar Branemark. “Osseo integration and its experimental back ground”. Research and Education, Journal of Prosthetic Dentistry 3 (1983): 399-409.
  8. Kim J Pansegrau., et al. “A comparative study of osseointegration of Titanium implants in Autogenous and Freeze-dried bone grafts”. Journal of Oral and Maxillofacial Surgery9 (1998): 1067-1074.
  9. JPM Fennis and PJW Stoelinga. “Mandibular reconstruction: A clinical and radiographic animal study on the use of autogenous scaffolds and platelet-rich plasma”. International Journal of Oral and Maxillofacial Surgery 3 (2002): 281-286.
  10. Su-Gwan Kim and Woon-Kyu Kim. “A comparative study of osseointegration of Avana implants in a demineralized freeze-dried bone alone or with platelet-rich plasma”. Journal of Oral and Maxillofacial Surgery9 (2002): 1018-1025.
  11. Arlene Rodriguez and George E Anastassov. “Maxillary sinus augmentation with deproteinated bovine bone and platelet rich plasma with simultaneous insertion of endosseous implants”. Journal of Oral and Maxillofacial Surgery2 (2003): 157-163.
  12. J Camilo Roldan., et al. “Bone formation in the presence of platelet-rich plasma vs bone morphogenetic protein-7”. Bone1 (2004): 80-90.
  13. B-H Choi., et al. “Effect of platelet-rich plasma on bone regeneration in autogenous bone graft”. International Journal of Oral and Maxillofacial Surgery1 (2004): 56-59.
  14. KA Schlegel and K Donath. “Denovo bone formation using bovine collagen and platelet-rich plasma”. Biomaterials 23 (2004): 5387-5393.
  15. Andres R Sanchez and Steven E Eckert. “Influence of platelet-rich plasma added to xenogeneic bone grafts on bone mineral density associated with dental implants”. International Journal of Oral and Maxillofacial Implants4 (2005): 526-532.
  16. Belli E., et al. “Autogenous platelet-rich plasma in combination with bovine-derived hydroxyapatite xenograft for treatment of a cystic lesion of the jaw”. Journal of Craniofacial Surgery6 (2005): 978-980.
  17. Kevin J Butterfield and Jeffrey Bennett. “Effect of platelet-rich plasma with autogenous bone graft for maxillary sinus augmentation in a rabbit model”. Journal of Oral and Maxillofacial Surgery 3 (2005): 370-376.
  18. Michael R Sarkar and Peter Augat. “Bone formation in a long bone defect model using a platelet-rich plasma-loaded collagen scaffold”. Biomaterials9 (2006): 1817-1823.
  19. Oral abstract-Mykle Jacobs.
  20. Takahiro Kanno and Tetsu Takahashi. “Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation”. Journal of Oral and Maxillofacial Surgery3 (2005): 362-369.
  21. David Gerard and Eric R Carlson. “Effects of platelet-rich plasma on the healing of autologous bone grafted mandibular defects in dogs”. Journal of Oral and Maxillofacial Surgery3 (2006): 443-451.
  22. Thorwarth M., et al. “PRP modulates expression of bone matrix proteins in vivo without long-term effects on bone formation”. Bone1 (2006): 30-40.
  23. Chawket Mannai. “Early implant loading in severely resorbed maxilla using xenograft, autograft, platelet-rich plasma in 97 patients”. Journal of Oral and Maxillofacial Surgery9 (2006): 1420-1426.
  24. Kochiashvili GT., et al. “Histological characteristics of stimulating role of hydroxy apatite and platelet rich plasma in reparative processes in experiment”. Georgian Medical News 133 (2006): 37-41.
  25. Plachokova AS and van den Dolder J. “The bone regenerative effect of plate-rich plasma in combination with an osteo conductive material in rat cranial defects”. Clinical Oral Implants Research 3 (2006): 305-311.
  26. Yoichiro Ogino., et al. “The contribution of platelet-derived growth factor, transforming growth factor-beta1, and insulin-like growth factor-I in platelet-rich plasma to the proliferation of osteoblast-like cells”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology6 (2006): 724-729.
  27. Luciano Malchiodi and Alessandro Quaranta. “Jaw reconstruction with grafted autologous bone: Early insertion of osseo integrated implants and early prosthetic loading”. Journal of Oral and Maxillofacial Surgery8 (2006): 1190-1198.
  28. G Schmidmaier and S Herrmann. “Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation”. Bone5 (2006): 1156-1163.
  29. Tae-Min You and Byung-Ho Choi. “The effect of platelet-rich plasma on bone healing around implants placed in bone defects treated with bio-oss: a pilot study in the dog tibia”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology4 (2007): e8-e12.
  30. Lewis Clayman. “Implant reconstruction of the bone-grafted maxilla: Review of the literature and presentation of 8 cases”. Journal of Oral and Maxillofacial Surgery4 (2006): 674-682.
  31. Metgud Sandeep and Halli Raj Shekar. “Single step apical barrier placement in immature teeth using mineral tri oxide aggregate and management of peri apical inflammatory lesion using platelet-rich plasma and hydroxy apatite”. Journal of Endodontics8 (2008): 1020-1024.
  32. Tae-Min you, Byung-Ho choi. “The effect of platelet rich plasma on bone healing around implants placed in bone defects treated with bio-oss a pilot study in dog tibia”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology4 (2007): e8-e12.
  33. A Thor and V Franke-Stenport. “Early bone formation in human bone grafts treated with platelet-rich plasma: preliminary histo morphometric results”. International Journal of Oral and Maxillofacial Surgery12 (2007): 1164-1171.
  34. Dental Abstracts, Oral and Maxillofacial Surgery Volume 52 (2007).
  35. Marcia Hatakeyama Master and Marcelo E Beletti. “Radiographic and Histomorphometric analysis of bone healing using autogenous graft associated with Platelet rich plasma obtained by 2 different methods”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology1 (2008): e13-e18.
  36. Jan Slapnicka and Antonin Fassman. “Effects of activated and non activated platelet-rich plasma on proliferation of human osteoblasts in vitro”. Journal of Oral and Maxillofacial Surgery 66 (2008): 297-301.
  37. Robert E Marx. “Platelet-rich plasma: Evidence to support its use”. Journal of Oral and Maxillofacial Surgery4 (2004): 489-496.
  38. Umashankar KV., et al. “Platelet-rich-plasma (PRP)-A novel approach for regeneration of the bony defects”. Indian Dentist Research and Review (2008): 44-53.
  39. Fennis JPM., et al. “Mandibular reconstruction: A clinical and radiographic animal study on the use of autogenous scaffolds and platelet-rich plasma”. International Journal of Oral and Maxillofacial Surgery3 (2002): 281-286.
  40. Fennis JPM., et al. “Mandibular reconstruction: a histological and histomorphometric study on the use of autogenous scaffolds, particulate cortico cancellous bone grafts and platelet rich plasma in goats”. International Journal of Oral and Maxillofacial Surgery1 (2004): 48-55.

Sudhanshu Agrawal., et al. “Regenerative Potential of Platelet-Rich Plasma-Enriched Autograft and Xenograft in Peri-Implant Deficient Sites: A Clinical and Radiological Study”. EC Dental Science 25.9 (2026): 01-09.

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