EC Dental Science

Preface

Fibroepithelioma of Pinkus was initially scripted in 1953 by Dr Hermann Pinkus and is an uncommon, premalignant, cutaneous epithelial neoplasm originally cogitated as an exceptional variant of basal cell carcinoma [1]. Currently, a controversy exists whether fibroepithelioma of Pinkus is a variant of basal cell carcinoma or a trichoblastoma. Aforesaid lesions are engendered from follicular epithelial stem cells discerned within the bulge area of hair follicle. Follicular stem cells further enunciate follicular germinative cells or trichoblasts which generate the components of folliculo- sebaceous- apocrine unit in its entirety [1]. Trichoblasts which engender trichoblastoma and basal cell carcinoma exemplify common epithelial keratins and differentiate towards outer hair root sheath along with companion layer of the hair follicle. Follicular cells which express hair keratins engender hair fibre whereas follicular cells manifesting adjunctive varieties of keratin generate the inner root sheath [1,2].

1. Pinkus H. “Premalignant fibroepithelial tumours of the skin”. Archives of Dermatology and Syphilology 67 (1953): 598-616.
2. Pinkus H. “Epithelial and fibroepithelial tumours”. Bulletin of the New York Academy of Medicine 41 (1965): 176-189.
3. Haddock ES and Cohen PR. “Fibroepithelioma of Pinkus Revisited”. Dermatology and Therapy3 (2016): 347-362.
4. Roldan-Marin R., et al. “Fibroepithelioma of Pinkus in continuity with a pigmented nodular basal cell carcinoma (BCC); a dermoscopic and histologic correlation". Journal of the American Academy of Dermatology 74 (2016): e91-e93.
5. Reggiani C., et al. “Fibroepithelioma of Pinkus: case reports and review of literature”. Dermatology 226 (2013): 207-211.
6. Peterson SC., et al. “Basal cell carcinoma preferentially arises from stem cells within hair follicles and mechanosensory niches”. Cell Stem Cell 6 (2015): 400-412.
7. Ataffi SS., et al. “Pinkus tumour: an unusual case”. Pathologica 105 (2013): 140-141.
8. Gutte RM. “Fibroepithelioma of Pinkus: a distinctive variant of trichoblastic carcinoma”. Indian Journal of Dermatology, Venereology and Leprology (2013).
9. Image 1 Courtesy: Dermpedia.
10. Image 2 Courtesy: Medscape emedicine.
11. Image 3 Courtesy: Springer link.
12. Image 4 Courtesy: Twitter.
13. Image 5 Courtesy: Slide player.
14. Image 6 Courtesy: Indian Journal of Dermatol Venereol Leprol.
15. Image 7 Courtesy: eScholarship.
16. Image 8 Courtesy: Histopathology.india.net.