EC Dental Science

Mini Review Volume 25 Issue 10 - 2026

Phytochemical-Based Nanotherapeutics in Oral Healthcare: Current Evidence, Challenges and Future Perspectives

Harpreet Singh1*, SJ Wadher2, Dinesh Kumar3 and Krishna Chaitanya Gunturu4

1Director, Research and Development, Desh Bhagat University SIRO, Dean Research, Professor and Head, Department of Conservative Dentistry and Endodontics, Desh Bhagat University, Mandi Gobindgarh, Punjab, India 2Senior Professor, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India 3Associate Professor, Department of Pharmaceutics, S. Lal Singh Memorial College of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India 4Professor, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India

*Corresponding Author: Harpreet Singh, Director, Research and Development, Desh Bhagat University SIRO, Dean Research, Professor and Head, Department of Conservative Dentistry and Endodontics, Desh Bhagat University, Mandi Gobindgarh, Punjab, India.
Received: September 26, 2026; Published: October 05, 2026



Phytochemicals have attracted vast interest in oral healthcare because of their antimicrobial, antibiofilm, anti-inflammatory and antioxidant properties. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, berberine and propolis- derived constituents have been investigated for their high potential in management of several dental problems. However, many phytochemicals have poor aqueous solubility, limited stability and low bioavailability, which restrict their therapeutic application. Nanotechnology offers a means of improving these limitations through nanoparticles, liposomes, nano emulsions, nanostructured lipid carriers, nanogels and mucoadhesive systems which may improve stability, local retention, controlled release and delivery to diseased tissues. This review summarizes important phytochemicals, relevant nanocarrier systems, current oral-health applications, clinical evidence, major limitations and future research priorities.

Keywords: Microbiome: Nanotechnology; Nanoparticles; Oral Healthcare; Phytochemicals

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Harpreet Singh., et al. “Phytochemical-Based Nanotherapeutics in Oral Healthcare: Current Evidence, Challenges and Future Perspectives”. EC Dental Science 25.10 (2026): 01-06.

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