EC Dental Science

Editorial Volume 22 Issue 2 - 2023

O3 in Oro-Dental Medicine and Surgery: Innovative Ozone-based Therapies

Ziyad S Haidar1-5*

1BioMAT’X (HAiDAR I+D+i LAB), Santiago, Chile
2Clínica Universidad de los Andes, Santiago, Chile
3Facultad de Odontología, Universidad de los Andes, Santiago, Chile
4Programa de Doctorado en BioMedicina, Facultad de Medicina, Universidad de los Andes, Santiago, Chile
5Centro de Investigación e Innovación Biomédica (CiiB), Facultad de Medicina, Universidad de los Andes, Santiago, Chile

*Corresponding Author: Ziyad S Haidar, DDS, Implantologist (Cert Implantol), Oral and Maxillofacial Surgeon (MSc OMFS), FRSC (Canada), FICD, MBA, PhD. Professor and Scientific Director, Faculty of Dentistry, Universidad de los Andes, Santiago de Chile. Founder and Head/Director of BioMAT’X R&D&I Research Group and Laboratory, (Laboratorio de Biomateriales, Farmacéuticos y Bioingeniería de Tejidos Cráneo Máxilo-Facial), Biomedical Research and Innovation Center/Centro de Investigación e Innovación Biomédica (CiiB), Faculty of Medicine, Department for Research, Development and Innovation, Universidad de los Andes, Avenida Mons, Las Condes, Santiago de Chile, Chile.
Received: December 01, 2022; Published: January 02, 2023

Keywords: O3; Ozone; Dentistry; Surgery; Anti-Microbial; Dental Caries; Dental Pain; Periodontal Diseases


Dentistry is ever-evolving. Our patients seek more choices and expect us to have the latest clinical advancements and technological innovations, in treatment. Increasingly, ozone, a super-charged or excited form of oxygen (inorganic oxygen with an extra atom; tri-oxygen where O + O2 + energy = O3), is showing its therapeutic potentiality in almost every sub-field of dentistry, including disinfection, tooth decay/dental caries, tooth sensitivity and dental pain, gingival and periodontal diseases as well as in dental implantology and oral surgery. E.A. Fisch, a German dentist in Switzerland used ozone in the 1930s, after its discovery and use in medicine in/since 1885. Whilst the first mention of ozone is often attributed to Dutch physicist Martin van Marun in 178, the German chemist Christian Friedrich Schönbein is widely regarded as the father of ozone therapy. Nikola Tesla patented an ozone-generating system, in 1896, followed by the more modern and innovative “Ozonosan” system patented by Joachim Hansler, in 1959.

  1. HO Kazancioglu., et al. “Effects of ozone therapy on pain, swelling, and trismus following third molar surgery”. International Journal of Oral and Maxillofacial Surgery 5 (2014): 644-648.
  2. El Hadary AA., et al. “Evaluation of the effect of ozonated plant oils on the quality of osseointegration of dental implants under the influence of Cyclosporin A an in vivo study”. Journal of Oral Implantology 2 (2011): 247-257.
  3. Nagayoshi M., et al. “Efficacy of ozone on survival and permeability of oral microorganisms”. Oral Microbiology and Immunology 4 (2004): 240-246.
  4. Matsamura K., et al. “A trial of regeneration of periodontal ligament around dental implants”. Journal of Dental Research 81 (2002): 101.
  5. MI Ramzy., et al. “Management of aggressive periodontitis using ozonized water”. Egypt Medical Journal N R C,1 (2005): 229-245.
  6. Sansriti Tiwari., et al. “Dental applications of ozone therapy: A review of literature”. The Saudi Journal for Dental Research1-2 (2017): 105-111.
  7. Safaa Ali Ghobashy., et al. “In vivo study of the effectiveness of ozonized olive oil gel on inhibiting enamel demineralization during orthodontic treatment”. Egyptian Orthodontic Journal 10 (2012): 657-666.
  8. A Agrillo., et al. “New therapeutic protocol in the treatment of avascular necrosis of the jaws”. Journal of Craniofacial Surgery 6 (2006): 1080-1083.
  9. AM Elvis and JS Ekta. “Ozone therapy: a clinical review”. Journal of Natural Science, Biology and Medicine 1 (2011): 66-70.
  10. Huang J., et al. “Topical ozone therapy: An innovative solution to patients with herpes zoster”. Zhong Nan Da Xue Xue Bao Yi Xue Ban2 (2018): 168-172.
  11. KC Huth., et al. “Effect of ozone on non-cavitated fissure carious lesions in permanent molars -a controlled prospective clinical study”. American Journal of Dentistry 4 (2005): 223-228.
  12. Nogales CG., et al. “Ozone therapy in medicine and dentistry”. Journal of Contemporary Dental Practice 4 (2008): 75-84.

Ziyad S Haidar. “O3 in Oro-Dental Medicine and Surgery: Innovative Ozone-based Therapies”.”. EC Dental Science 22.2 (2023): 01-04.