Review Article Volume 25 Issue 10 - 2026

Models of Pathogens in Periodontitis

Swathi S*, Arjun MR, Sana Ansar and Sajini Mol B Saji

Department of Periodontics, Pondicherry, India

*Corresponding Author: Swathi S, Department of Periodontics, Pondicherry, India.
Received: August 12, 2026; Published: October 05, 2026



Periodontitis is a long-lasting inflammatory disease influenced by various factors, including microbial biofilm, the immune re- sponse of the host, genetics, and environmental elements. Different models have been suggested to clarify its development, starting from simple plaque-based theories to more intricate nonlinear and systems-oriented ideas. The Page and Schroeder model outlined the histopathological changes, while subsequent models incorporated host vulnerability and risk factors. Newer ideas like the key- stone pathogen, polymicrobial dysbiosis, and immunomicrobial models portray periodontitis as a cycle involving chronic inflamma- tion, microbial imbalance, and tissue damage. Contemporary biological systems approaches could enhance personalized diagnosis and treatment. Grasping these models is crucial for improving periodontal care.

Keywords: Periodontitis; Microbial Biofilm; Page and Schroeder Model; Periodontal Care

  1. Avula Haritha and Yashaswini Chakravarthy. “Models of periodontal disease pathogenesis: a journey through time”. Journal of Indian Society of Periodontology3 (2022): 204-212.
  2. Valerie Anithra Pereira., et al. “A review on models of pathogenesis in periodontitis”. International Journal of Advanced Research12 (2017): 1115-1124.
  3. Kornman KS. “Mapping the pathogenesis of periodontitis: A new look”. Journal of Periodontology8 (2008): 1560-1568.
  4. Loe H., et al. “Experimental gingivitis in man”. Journal of Periodontology 36 (1965): 177-187.
  5. Page RC and Schroeder HE. “Pathogenesis of inflammatory periodontal disease. A summary of current work”. Laboratory Investigation 3 (1976): 235-249.
  6. Hajishengallis G., et al. “Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy”. Periodontology 20001 (2020): 14-34.
  7. Socransky SS. “Microbiology of periodontal disease - Present status and future considerations”. Journal of Periodontology9 (1977): 497-504.
  8. Slots J. “Subgingival microflora and periodontal disease”. Journal of Clinical Periodontology5 (1979): 351-382.
  9. Van Dyke TE. “Role of the neutrophil in oral disease: Receptor deficiency in leukocytes from patients with juvenile periodontitis”. Reviews of Infectious Diseases 3 (1985): 419-425.
  10. Offenbacher S. “Periodontal diseases: Pathogenesis”. Annals of Periodontology 1 (1996): 821-878.
  11. Loe H., et al. “Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age”. Journal of Clinical Periodontology5 (1986): 431-445.
  12. Page RC and Kornman KS. “The pathogenesis of human periodontitis: An introduction”. Periodontology 2000 14 (1997): 9-11.
  13. Bergstrom J. “Periodontitis and smoking: An evidence based appraisal”. Journal of Evidence-Based Dental Practice 1 (2006): 33-41.
  14. Darveau RP. “The oral microbial consortium’s interaction with the periodontal innate defense system”. DNA and Cell Biology 8 (2009): 389-395.
  15. Genco RJ., et al. “1985 Kreshover lecture. Molecular factors influencing neutrophil defects in periodontal disease”. Journal of Dental Research 65 (1986): 1379-1391.
  16. Genco RJ. “Current view of risk factors for periodontal diseases”. Journal of Periodontology10 (1996): 1041-1049.
  17. George Hajishengallis. “Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response”. Trends in Immunology 1 (2015): 3-11.

Swathi S., et al. “Models of Pathogens in Periodontitis”. EC Dental Science 25.10 (2026): 01-10.