EC Dental Science

Muco-cutaneous ulcer infected with and immune reactive to Epstein Barr virus (EBV+MCU) is a contemporary clinico-pathological entity, as denominated by World Health Organization (WHO) diagnostic criteria revised in 2017. The disorder was previously designated as a lymphoproliferative lesion accompanied with isolated cutaneous or mucosal ulcerative lesions.

Generally, EBV+ muco-cutaneous ulcer incriminates elderly population or immunosuppressed individuals. Majority (~90%) of adult population is infected with Epstein Barr virus through the oral route wherein infections predominantly occur within early life.

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5. Bott P., et al. “Co-Occurrence of EBV-Positive Mucocutaneous Ulcer (EBV-MCU) and CLL/SLL in the Head and Neck Region”. Current Oncology4 (2022): 2749-2767.
6. Image 1 Courtesy: Research gate.
7. Image 2 Courtesy: Science direct.