EC Dental Science

Hydroa vacciniforme is an exceptional photodermatosis of obscure pathogenesis incriminating the paediatric population. Characteristically, vesicular lesions are encountered which heal with scarring. Besides, Epstein Barr virus (EBV) can be discerned within the accompanying dermal lymphocytic infiltrate.

Hydroa vacciniforme-like cutaneous lymphoma is a chronic cutaneous lymphoproliferative disorder demonstrating a varied clinical spectrum. Occurring as a consequence to infection with Epstein Barr virus (EBV), the lymphoma generally manifests with a prolonged clinical course along with possible, delayed progression into a systemic lymphoma.

1. Quintanilla-Martinez L., et al. “New concepts in EBV-associated B, T, and NK cell lymphoproliferative disorders”. Virchows Archiv (2022).
2. Plaza JA., et al. “An Update on Viral Induced Cutaneous Lymphoproliferative Disorders. A Review from the Ibero-American Society of Dermatopathology (SILADEPA). CME Part I”. Journal of the American Academy of Dermatology (2022): S0190-9622.
3. Rice AS and Bermudez R. “Hydroa Vacciniforme”. Stat Pearls International, Treasure Island, Florida (2022).
4. Grześk E., et al. “Case report: Cellular therapy for hydroa vacciniforme-like lymphoproliferative disorder in paediatric common variable immunodeficiency with chronic active Epstein-Barr virus infection”. Frontiers in Immunology 13 (2022): 915986.
5. Image 1 Courtesy: Dermnet NZ.
6. Image 2 Courtesy: Science direct.