EC Dental Science

Narrative Review Volume 22 Issue 6 - 2023

Knowing Bisphosphonates and the Potential Use in Dentistry

Stefano Rosini1 and Luigi Molfetta2*

1 Smile-Restyle, Livorno, Italy
2University of Genoa, DISC Department, School of Medical and Pharmaceutical Sciences, Research Center of Osteoporosis and Osteoarticular Pathologies, Italy

*Corresponding Author: Luigi Molfetta, Professor, University of Genoa, DISC Department, School of Medical and Pharmaceutical Sciences, Research Center of Osteoporosis and Osteoarticular Pathologies, Italy.
Received: April 21, 2023; Published: June 23, 2023



Bisphosphonates (BPs) are compounds which reduce the rate of bone turnover and affect the activity of several bone cells like the osteoclasts, osteoblasts and osteocytes. BPs have been used for the treatment of bone diseases characterised by high turnover (Paget’s disease of bone, hypercalcemia of malignancy) and osteoporosis by reducing the turnover rate and increasing the bone density. BPs are avidly absorbed by the bone and, on a special way, by the area subjected to remodeling either for physiological needings or as consequence of inflammatory conditions. Bisphosphonates bind to the bone mineral and are retained buried in the bone for extended period of time which vary from weeks, months up to years. The capability to prevent the bone loss has also stimulated investigations on the potential use in the field of dentistry where the BPs can be used systemically or by local application.

Keywords: Bisphosphonates; Dentistry; Bone Remodeling; Periodontal Disease; Implantology

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Stefano Rosini and Luigi Molfetta. "Knowing Bisphosphonates and the Potential Use in Dentistry". EC Dental Science 22.6 (2023): 92-101.