EC Dental Science

Research Article Volume 13 Issue 6 - 2017

Higher Prevalence of HLA-DQB1*0301 in Non-Diabetic Mestee Subjects with Chronic Periodontitis

Adriano MA Monteiro1*, Songeli M Freire2, Maria T Bendicho2, Roberto Meyer2, Isaac S Gomes-Filho3, Urbino R Tunes4, Carine Schitini Pinheiro5, Soraya Castro Trindade3 and Denise C Lemaire2

1PhD in Immunology, Department of Health, Southwest State University, Bahia, Brazil
2PhD in Immunology, Department of Health, Federal University of Bahia, Bahia, Brazil
3PhD in Periodontics, Department of Health, Feira de Santana, State University, Bahia, Brazil
4PhD in Immunology, Department of Health, Bahiana Faculty for Development of Science, Bahia, Brazil
5MD in Odontology, Department of Health, Bahiana Faculty for Development of Science, Bahia, Brazil

*Corresponding Author: Adriano Monteiro d’Almeida Monteiro, Department of Health, Southwest State University, R. Conselheiro Cor- reia de Menezes, Ed Mansão Imperial Boulevard, Horto Flrestal, Salvador, Bahia, Brazil.
Received: August 16, 2017; Published: September 04, 2017



Objective: The aim of this study was to investigate and to compare the distribution of HLA alleles, genotypes and haplotypes among diabetic subjects with or without severe chronic periodontal disease and non-diabetic subjects with severe chronic periodontal disease.

Materials and Methods: 91 subjects were tested and divided into three groups: DP was formed by 31 diabetic subjects with severe chronic periodontal disease; DWP consisted of 30 diabetic subjects without periodontitis; and NDP was formed by 30 metabolically healthy patients with severe chronic periodontal disease. The polymorphisms studied were HLA-DRB1, -DRB3/4/5 and -DQB1. The data were transferred for a Generic HLA Class II DNA Typing Tray map to determine allele, genotype and haplotype results.

Results: No statistically significant differences were found for allele and genotypic frequencies on HLA-DRB1 and HLA-DRB3/4/5 genes. Furthermore, no statistically significant differences were found for haplotypic frequencies among the three groups. The ge- notypic frequency of HLA-DQB1*0301 was found at a significantly higher level in NDP patients than in the DP group (p = 0.0402).

Conclusions:In metabolically healthy mestee patients with chronic periodontal disease from Bahia, Brazil, there is a significant as- sociation with HLA-DQB1*0301. Further studies with a bigger population are warranted to confirm these results.

Keywords: Chronic Periodontitis; Human Leukocyte Antigens; Diabetes Mellitus; Polymorphism

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Adriano MA Monteiro., et al. “Higher Prevalence of HLA-DQB1*0301 in Non-Diabetic Mestee Subjects with Chronic Periodontitis”.”. EC Dental Science 13.6 (2017): 252-260.

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