EC Dental Science

Literature Review Volume 22 Issue 3 - 2023

Hereditary Gingival Fibromatosis: A Short Review of the Literature

Rebeca Serrano Zamora1, Carmen Mallagray1, Carlos M Cobo Vázquez2,3* and Juan López Quiles4

1Oral Surgery and Implantology Master Student, Department of Clinical Specialities, Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain
2Associate Dentist, Department of Stomatology and Dentistry, Gregorio Marañón University General Hospital, Spain
3Associate Professor, Department of Clinical Specialities, Faculty of Dentistry, Complutense University of Madrid, Spain
4Titular Professor, Department of Clinical Specialities, Faculty of Dentistry, Complutense University of Madrid, Spain

*Corresponding Author: Carlos M Cobo Vázquez, Associate Dentist, Department of Stomatology and Dentistry, Gregorio Marañón University General Hospital, Spain.
Received: November 10, 2022; Published: February 09, 2023



Introduction: Hereditary gingival fibromatosis (HGF) is an uncommon, inherited disorder with slow and progressive fibrous hyperplasia of the gingiva. The excess gingival tissues can cause dental, masticatory and phonetic problems, which cause functional and esthetic problems.

Objective: To describe the main epidemiology, clinical signs, symptoms, histopathological and therapeutic aspects of HGF.

Materials and Methods: A comprehensive search of the literature was conducted in the PubMed/MEDLINE (National Library of Medicine) and Web of Science electronic databases. The search strategy was done using the following terms: “hereditary gingival fibromatosis”, “palatal fibromatosis”, “gingival fibromatosis”.

Results: Discuss the main clinical characteristics, diagnosis and treatment of HGF found in the literature.

Conclusion: HGF is an uncommon condition that causes enlargement of the gingival tissues affecting the maxilla or mandible. Its diagnosis is based on clinical observation, family history and histological analysis. Although the prediction of recurrence after surgical treatment is difficult to estimate, it is necessary to prevent patient discomfort.

Keywords: Hereditary Gingival Fibromatosis; Palatal Fibromatosis; Gingival Fibromatosis

  1. Carli E., et al. “Periodontology Part 3: Hereditary Gingival Fibromatosis (HGF): from diagnosis to treatment in the paediatric age”. European Journal of Paediatric Dentistry 3 (2022): 249-250.
  2. Afonso RA., et al. “Hereditary Gingival Fibromatosis and Developmental Anomalies: A Case Report”. Cureus 4 (2022): e24219.
  3. Roman-Malo L., et al. “Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis”. Diseases2 (2019): 39.
  4. Kamal NM., et al. “Expression of TGF-β and MMP-2 in hereditary gingival fibromatosis epithelial cells. A possible contribution of the epithelium to its pathogenesis”. Journal of Oral Biology and Craniofacial Research 5 (2022): 617-622.
  5. Boutiou E., et al. “Hereditary gingival fibromatosis in children: a systematic review of the literature”. Clinical Oral Investigations 6 (2021): 3599-3607.
  6. Strzelec K., et al. “Clinics and genetic background of hereditary gingival fibromatosis”. Orphanet Journal of Rare Diseases 1 (2021): 492.
  7. Wu J., et al. “A novel gene ZNF862 causes hereditary gingival fibromatosis”. Elife 11 (2022): e66646.
  8. Vargo RJ., et al. “Symmetrical palatal fibromatosis: Five new cases and a review of the literature”. Oral Diseases 3 (2019): 781-787.
  9. Cunha JLS., et al. “Generalized hereditary gingival fibromatosis in a child: clinical, histopathological and therapeutic aspects”. Autopsy and Case Reports 1 (2020): e2020140.
  10. Ferreira Gonçalves C., et al. “Hereditary Gingival Fibromatosis: a Case Report with Seven-Year Follow-up”. Acta Stomatologica Croatica 3 (2018): 254-258.
  11. Gao H., et al. “Unusual clinical and histologic findings in a child with mixed dentition with hereditary gingival fibromatosis: a case report”. Translational Pediatrics 1 (2020): 74-80.
  12. Mariani P., et al. “Hereditary gingival fibromatosis associated with the missense mutation of the KCNK4 gene”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 6 (2021): e175-e182.
  13. Kantaputra PN., et al. “Enamel–renal–gingival syndrome, hypodontia, and a novel FAM20A mutation”. American Journal of Medical Genetics 164 (2014): 2124-2128.
  14. La Dure-Molla M., et al. “Pathognomonic oral profile of enamel renal syndrome (ERS) caused by recessive FAM20A mutations”. Orphanet Journal of Rare Diseases 9 (2014): 1-13.
  15. Guglielmi F., et al. “Zimmermann-Laband-1 Syndrome: Clinical, Histological, and Proteomic Findings of a 3-Year-Old Patient with Hereditary Gingival Fibromatosis”. Biomedicines 3 (2019): 48.
  16. Rauen KA. “HRAS and the Costello syndrome”. Clinical Genetics 71 (2007): 101-108.
  17. Tidyman WE and Rauen KA. “The RASopathies: Developmental syndromes of Ras/MAPK pathway dysregulation”. Current Opinion in Genetics and Development 19 (2009): 230-236.
  18. Goodwin AF., et al. “Craniofacial and dental development in Costello syndrome”. American Journal of Medical Genetics A 6 (2014): 1425-1430.
  19. Haytac MC and Ozcelik O. “The phenotypic overlap of syndromes associated with hereditary gingival fibromatosis: follow-up of a family for five years”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 103 (2007): 521-527.
  20. Kalgaonkar PS., et al. “Juvenile Hyaline Fibromatosis- A Rare Autosomal Recessive Disease”. Journal of Clinical and Diagnostic Research 7 (2017): SD04-SD06.
  21. Shin HT., et al. “Infantile systemic hyalinosis”. Journal of the American Academy of Dermatology 50 (2004): S61-S64.
  22. Burbridge KA., et al. “Prune belly syndrome: 35 years of experience”. The Journal of Urology 137 (1987): 86-90.
  23. Ramon Y., et al. “Gingival fibromatosis combined with cherubism”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 24 (1967): 436-448.
  24. Gawron K., et al. “Gingival fibromatosis: clinical, molecular and therapeutic issues”. Orphanet Journal of Rare Diseases 11 (2016): 9.
  25. Coletta RD and Graner E. “Hereditary gingival fibromatosis: a systematic review”. Journal of Periodontology 5 (2006): 753-764.

Carlos M Cobo Vázquez., et al. “Hereditary Gingival Fibromatosis: A Short Review of the Literature”.”. EC Dental Science 22.3 (2023): 11-18.