EC Dental Science

Sclerosing microcystic adenocarcinoma is an exceedingly exceptional, unique, primary salivary gland neoplasm. Additionally designated as microcystic adnexal carcinoma, sclerosing sweat duct carcinoma of intraoral minor salivary glands or syringomatous adenocarcinoma not otherwise specified (NOS), sclerosing microcystic adenocarcinoma presumably arises from minor salivary glands confined to head and neck region. The infrequent, low grade tumefaction exemplifies significant morphological concurrence with cutaneous microcystic adnexal carcinoma.

Commonly incriminating minor salivary glands, immunosuppression may be implicated in disease pathogenesis. Tumefaction is confined to mucosal sites within head and neck region.

Sclerosing microcystic adenocarcinoma is constituted of bland ducts, tubules, cords and cellular nests of variable magnitude. Neoplasm is constituted of biphasic population of intrinsic cuboidal epithelial cells and extraneous myoepithelial cells circumscribed by an abundant, dense, sclerotic or collagenous stroma. Tumefaction appears intensely infiltrative into circumscribing soft tissues. Perineural invasion and infiltration into abutting skeletal muscle is preponderant.

1. Lee YY., et al. “Sclerosing Microcystic Adenocarcinoma Arising from the Tongue: A Case Report and Literature Review”. Diagnostics 5 (2022): 1288.
2. Nishida H., et al. “Histopathological Aspects of the Prognostic Factors for Salivary Gland Cancers”. Cancers 4 (2023): 1236.
3. Tan GZL., et al. “Sclerosing microcystic adenocarcinoma of the parotid gland-The first recorded case with histo-cytopathologic correlation and a brief review of the literature”. Annals of Diagnostic Pathology 54 (2021): 151806.
4. Jiang R., et al. “Sequencing of sclerosing microcystic adenocarcinoma identifies mutational burden and somatic variants associated with tumorigenesis”. Anticancer Research 40 (2020): 6375-6379.
5. Zhang R., et al. “Sclerosing microcystic adenocarcinoma: Report of a rare case and review of literature”. Head and Neck Pathology 13 (2019): 215-219.
6. Image 1 Courtesy: Pathology outlines.
7. Image 2 Courtesy: Research gate.