EC Dental Science

Introduction: The treatment of furcation defects has been a subject of extensive research, with various materials being utilized to achieve optimal regeneration. Platelet-rich fibrin (PRF) is a pool of growth-promoting factors and cytokines that have shown promising results in tissue regeneration. Zoledronate (ZLN), a third-generation Bisphosphonate (BP), is the most potent in its class, with the highest bone affinity. Both local and systemic treatments of Zoledronate have demonstrated positive outcomes in implants.

Objective: This case report aims to evaluate the effectiveness of a combination of PRF, 0.05% Zoledronate gel, and bone graft for the management of furcation defects.

Methodology: A conventional flap surgery was performed on a molar furcation defect, and the defect was treated with a combination of PRF, 0.05% ZLN gel, and bone graft. Clinical parameters, including plaque index, sulcus bleeding index, vertical probing depth, relative vertical and horizontal clinical attachment level, and gingival marginal level, were recorded at baseline and 6 months post-operatively. Radiographic assessment was conducted to evaluate the percentage of defect fill at baseline and 6 months post-surgery.

Result: The treatment resulted in a significant reduction in probing depth, gain in clinical attachment level, and improved bone fill.

Conclusion: The combination of autologous PRF, 0.05% Zoledronate gel, and bone graft demonstrated a favorable therapeutic outcome both clinically and radiographically in the management of furcation defects. This treatment approach holds promise for the effective management of furcation defects and warrants further investigation.

Keywords: Periodontitis; Zoledronate; Platelet Rich Fibrin; Bone Graft; Furcation; Defect

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