EC Dental Science

Endorphins are endogenous opioids, neuropeptides, synthesize and stored in the pituitary gland. Beta-endorphin is an abundant endorphin, more potent than morphine, and binds with its µ receptors situated on the nervous system and immune cells. Which are involved in analgesic, anti-inflammatory, stress buster, and immune stimulatory activity. Because of these mechanisms of action, beta-endorphin can be used in the holistic management of cancer, autoimmune disease, psychological disease, neurodegenerative diseases, metabolic diseases, headaches, muscle spasms, and hormonal imbalances without adverse effects and is inexpensive. This article explains about beta-endorphin mechanisms of actions in chronic psychological stress-induced activation of HPA-axis-mediated various diseases.

 Keywords: HPA-Axis; NF-kB; STAT-3; ANS; IL-1; IL-6; TNF-α; IL-17; Tregs; TGF-β

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