EC Dental Science

Angiofibroma of soft tissue is a benign, well defined, fibroblastic neoplasm incriminating soft tissues of extremities. Arising in concurrence with joints or fibrotendinous structures, tumefaction is comprised of uniform, spindle shaped cells intermingled within a variably myxoid and collagenous stroma imbued with a network of thin walled, branching vascular articulations. Cytogenetically, neoplasm delineates NCOA2 genetic rearrangements.

Angiofibroma of soft tissue commonly appears within middle aged adults and demonstrates a wide age of disease emergence ranging from 6 years to 68 years. A mild female preponderance is encountered.

Typically, angiofibroma of soft tissue is confined to lower extremities although sites involving or adjacent to large joints as knee joint may be incriminated. Besides, locales such as dorsal region, abdominal wall, pelvic cavity or breast may be infrequently incriminated [1,2].

1. Kao EY and Mantilla JG. “What's new in soft tissue and bone pathology 2022-updates from the WHO classification 5th edition”. Journal of Pathology and Translational Medicine 6 (2022): 385-386.
2. Wang C., et al. “Angiofibroma of Soft Tissue: A Clinicopathological Study of Eight Cases with Emphasis on the Diagnostic Utility of Fluorescence in Situ Hybridization Detection for NCOA2 Rearrangement”. Frontiers in Oncology 12 (2022): 900411.
3. Nakayama S., et al. “Angiofibroma of soft tissue: Current status of pathology and genetics”. Histology and Histopathology8 (2022): 717-722.
4. Uemura K., et al. “CYP1A1 Is a Useful Diagnostic Marker for Angiofibroma of Soft Tissue”. The American Journal of Surgical Pathology (2023).
5. Nakayama S., et al. “Arthroscopic Excision of Intra-articular AHRR-NCOA2- positive Angiofibroma of Soft Tissue of the Knee: A Case Report”. Cancer Diagnosis and Prognosis5 (2022): 592-597.
6. Image 1 Courtesy: Pathology outlines.
7. Image 2 Courtesy: Cureus.com.