EC Dental Science

The IPG-DET technique integrates precise implant positioning with controlled osteotomy, drills expansion and compactors - expanders, enabling implant placement into the sinus safely and minimally invasively - without Sinus Floor Elevation (S.F.E.) such as the need for a lateral window approach.

A clinical case reports a 60-year-old male patient who underwent implant placement in the atrophic posterior left maxilla with the innovative IPG-DET technique. This approach involves the intentional perforation of the Schneiderian membrane, followed by the application of autologous concentrated growth factors (CGF), a CD34+ stem cell matrix obtained via centrifugation and cell separation of the patient's intravenous blood, and mesenchymal stem cells (MSCs) derived from human umbilical cord tissue in the reconstruction of posterior maxilla.

The technique was developed as a minimally invasive alternative for posterior maxillary reconstruction, aiming to promote sinus regeneration, reduce intraoperative bleeding and both intra- and postoperative complications, and shorten the overall duration required for implant placement in the challenging posterior maxilla.

In this case, we investigate the effectiveness and healing response for osseointegration, associated with the integration of Mesenchymal Stem Cells (MSCs) derived from human umbilical cord blood in the reconstruction of the posterior atrophic maxilla. Preliminary outcomes indicate successful and safe bone regeneration within the sinus cavity.

 Keywords: Umbilical Cord Blood Stem Cells; Bone Augmentation; IPG-DET Technique; Intentional Sinus Membrane Perforation; Osseointegration; Concentrated Growth Factors and CD34+ Stem Cells

1. Inchingolo., et al. “Computer-based quantification of an atraumatic sinus augmentation technique using CBCT”. Journal of Biological Regulators and Homeostatic Agents 33.6 (2019): 31-39.
2. Ioannis P Georgakopoulos., et al. “Minimally invasive “IPG-Det Technique” with autologous CGF and human umbilical cord blood derived mesenchymal stem cells towards posterior atrophic maxilla reconstruction-case report”. EC Dental Science5 (2021): 43-50.
3. Shaily M Bhola., et al. “Povidone-iodine as a corrosion inhibitor towards a low modulus beta Ti-45Nb implant alloy in a simulated body fluid”. Journal of Materials Science: Materials in Medicine 4 (2011): 773-779.
4. Rahul Bhola., et al. “Effect of povidone-iodine addition on the corrosion behavior of cp-Ti in normal saline”. Journal of Materials Science: Materials in Medicine 5 (2011): 1413-1420.
5. Akhila., et al. “Review article sinus floor elevation techniques”. IP International Journal of Maxillofacial Imaging 8.3 (2022): 96-100.
6. Abdulrahman M Alshamrani., et al. “Maxillary sinus lift procedures: An overview of current techniques, presurgical evaluation, and complications”. Cureus11 (2023): e49553.
7. Vasileios Ntontoulos., et al. “Innovative “IPG-DET technique” combined with autologous CGF with stem cells CD34+ for the rehabilitation of the posterior atrophic maxilla”. EC Dental Science9 (2020): 119-126.
8. Shanaghi A., et al. “Povidone-iodine as a corrosion inhibitor towards a low modulus beta Ti-45Nb implant alloy in simulated body fluid”. Materials Chemistry and Physics 252 (2020): 123164.
9. Huang HH., et al. “Effect of povidone-iodine addition on the corrosion behavior of cp-Ti in normal saline”. Biomaterials13 (2001): 1741-1745.
10. Zhang., et al. “Liquid phase concentrated growth factor improves autologous fat graft survival in vivo in nude mice”. Aesthetic Plastic Surgery 45.5 (2021): 2417-2422.