EC Dental Science

Inflammation is a defensive mechanism against noxious stimuli such as physical or chemical or thermal injury. During inflammation various mediators are released such as chemokines, cytokines, enzymes and growth factors from inflammatory innate and adaptive immune cells for regeneration and repair. Chemokines are chemotactic cytokines released from inflammatory cells such as leucocytes involved in recruitment of immune cells to the site of inflammation. Cytokines are inflammatory mediators secreted by innate and adaptive immune cells such as neutrophils, macrophages, mast cells, dendritic cells, NK cells, T cells, and B cells. Growth factors such as EGF, FGF, VEGF, produced by immune cells involved in cell proliferation, cell survival, angiogenesis, by activating transcription factors NF-KB and STAt-3 work together.