EC Dental Science

Several studies have reported that up to 90% of HIV-infected patients exhibit one or more oral lesions at some time during their disease. Oral lesions are widespread in patients suffering from HIV infection. Oral health care workers caring for HIV-afflicted people/children ought to be aware of the various oral manifestations of HIV and detailed knowledge about staging and managing the same.

Children with HIV/AIDS are usually infected due to vertical transmission from mother to child or due to being victims of sexual exploitation. Owing to their innocent age and lack of awareness, they may not even understand the gravity of their health condition and suffer during the advanced stages of immunosuppression.

Increasing the intensity of immunological suppression leads to pronounced and characteristic oral changes. Early detection is the key to diagnosis and management, and it helps to reduce morbidity and improve the quality of life in these unfortunate children.

Keywords: HIV; AIDS; Children; Candidiasis; Infection

1. Origins of HIV and the AIDS Pandemic Paul M. Sharp1 and Beatrice H. Hahn2 Cold Spring Harb Perspectives in Medicine1 (2011): a006841.
2. Emerging and Reemerging Viral Pathogens: Volume 1: Fundamental Virology Aspects of Human, Animal and Plant Pathogens (2020): 183-200.
3. Action, innovation, and solidarity: A status report on the response to HIV in western and central Africa, The human impact of HIV in central and west Africa, UNAIDS (2018): 5-6.
4. Joint United Nations Programme on HIV/AIDS (UNAIDS). Data 2019. Geneva: UNAIDS (2019).
5. World Health Organization. Second WHO model list of essential in vitro diagnostics. Geneva: WHO; (2019).
6. World Health Organization. Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy. Geneva: WHO (2017).
7. Global information and education on HIV and aids, children, HIV, and AIDS, Quoted by AVERT, Cohn J., et al. “Paediatric HIV testing beyond the context of prevention of mother-to-child transmission: a systematic review and meta-analysis”. The Lancet HIV (2016).
8. Cohn J., et al. “Paediatric HIV testing beyond the context of prevention of mother-to-child transmission: a systematic review and meta-analysis”. The Lancet HIV (2016).
9. Anouk A., et al. “Promoting a Combination Approach to Paediatric HIV Psychosocial Support”. AIDS2 (2013): 147-157.
10. UNAIDS Get on the Fast Track: Chapter the Life Cycle Approach to HIV (2016).
11. Chandrashekhar Sandeep Kumar. “OHIV/AIDS and Children”. International Journal of Nursing Education and Research4 (2020): 564-568.
12. “Revision of the case definition of acquired immunodeficiency syndrome for national reporting United States”. Morbidity and Mortality Weekly Report 34 (1985): 373-375.
13. C Rajeswari., et al. “Anti-Retro Viral Therapy (ART) Adherence and Factors Affecting Adherence among People Living with HIV (PLHIVs)”. Asian Journal of Nursing Education and Research 3 (2017): 337-340.
14. Vinay Kumar G., et al. “A Study to assess the Quality of life of People Living with HIV/AIDS receiving Anti-Retroviral Therapy from the selected Anti-Retroviral Therapy centres of Mysore”. International Journal of Advances in Nursing Management 2 (2014): 90-92.
15. Juliet Sylvia. “A Framework for a Nurse-Led Youth Friendly Reproductive and Sexual Health Services (YFRSHS) For HIV/Aids Prevention”. International Journal of Advances in Nursing Management 2 (2015): 152-154.
16. Shweta Grigson. “A Study to assess the Effectiveness of Planned Teaching Program on Knowledge regarding HIV/AIDS among the students studying in selected schools at Damoh”. International Journal of Advances in Nursing Management 3 (2019): 240-242.
17. Emmanuel N Tufon., et al. “Occurrence and Risk Factors for Opportunistic Infections in HIV Patients Attending the Bamenda Regional Hospital, Cameroon”. International Journal of Nursing Education and Research 4 (2014): 381-384.
18. Johnson NW. “The mouth in HIV/AIDS: markers of disease status and management challenges for the dental profession”. Australian Dental Journal 1 (2010): 85-102.
19. Kalpidis CD., et al. “Gingival involvement in a case series of patients with acquired immunodeficiency syndrome-related Kaposi sarcoma”. Journal of Periodontology 3 (2006): 523-533.
20. Khongkunthian P., et al. “Oral manifestations in 45 HIV-positive children from Northern Thailand”. Journal of Oral Pathology and Medicine 9 (2001): 549-552.
21. Magalhaes MG., et al. “Oral manifestations of HIV positive children”. Journal of Clinical Pediatric Dentistry 2 (2001): 103-106.
22. Massarente DB., et al. “Oral health-related quality of life of paediatric patients with AIDS”. BMC Oral Health 11 (2011): 2.
23. Mittal MAIDS in children--epidemiology, clinical course, oral manifestations, and management”. Journal of Clinical Pediatric Dentistry 2 (2009): 95-102.
24. Piguet V., et al. “The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors”. Immunological Reviews 168 (1999): 51-63.
25. Bernard AL., et al. “Leukocyte typing”. Springer-Verlag, Heidelberg (1984): 45-48.
26. Harvey RA., et al. “Lippincott's illustrated reviews: Microbiology (Lippincott's Illustrated Reviews Series)”. 2^nd Hagerstown, MD: Lippincott Williams and Wilkins (2006): 432.
27. Aubert M., et al. “The Virological synapse facilitates herpes simplex virus entry into T cells”. Journal of Virology 12 (2009): 6171-6183.
28. Baccaglini L., et al. “Management of oral lesions in HIV-positive patients”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 103 (2007): S50.e1-23.
29. Greenspan D and Greenspan JS. “Oral mucosal manifestations of AIDS?” Dermatologic Clinics 4 (1987): 733-737.
30. Patt On LL., et al. “Prevalence and classification of HIV-associated oral lesions”. Oral Diseases 2 (2002): 98-109.
31. Reznik DA. “Oral manifestations of HIV disease”. Top HIV Medicines 5 (2005): 143-148.
32. Greenspan D., et al. “Risk factors for rapid progression from hairy leukoplakia to AIDS: a nested case-control study”. Journal of Acquired Immune Deficiency Syndromes 7 (1991): 652-658.