EC Dental Science

Nasopharyngeal carcinoma emerges within nasopharynx which is layered by nasopharyngeal mucosa demonstrating histologic and phenotypic differentiation into squamous epithelium. Majority of neoplasms occurring within endemic areas are immune reactive to Epstein-Barr virus (EBV) or Epstein-Barr encoded RNA (EBER). A subset of neoplasms may concur with high-risk variants of human papillomavirus (HPV).

1. Ben-Ami T., et al. “Nasopharyngeal carcinoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations”. Pediatric Blood and Cancer 68 (2021): e29018.
2. Adoga AA., et al. “The epidemiology, treatment and determinants of outcome of primary head and neck cancers at the Jos University Teaching Hospital”. The South Asian Journal of Cancer3 (2018): 183-187.
3. Römer T., et al. “Multimodal Treatment of Nasopharyngeal Carcinoma in Children, Adolescents and Young Adults-Extended Follow-Up of the NPC-2003-GPOH Study Cohort and Patients of the Interim Cohort”. Cancers5 (2022): 1261.
4. Sun L., et al. “Association of Plasma Epstein-Barr Virus LMP1 and EBER1 with Circulating Tumour Cells and the Metastasis of Nasopharyngeal Carcinoma”. Pathology and Oncology Research3 (2020): 1893-1901.
5. Image 1 Courtesy: Libre Pathology.
6. Image 2 Courtesy: Science direct.