EC Cardiology

RNA vaccines are appealing because they share traits with live-attenuated vectors and subunit vaccines, such as flexible manufacturing and generating humoral and cellular resistance. In recent years, vaccine production employing ribonucleic acid (RNA) has emerged as the most promising and explored strategy for producing safe and effective novel vaccines, not just for prevention but also as a therapy. Compared to conventional vaccines, using messenger RNA (mRNA) as an immunogen offers various benefits in vaccine production, including a cheaper cost, the absence of cell cultures, and the ability to mix diverse targets.

Most significantly, mRNA-based vaccines have the potential to bridge the gap between growing pandemic infectious illnesses and an ample supply of effective vaccinations. Despite its advantages for vaccine application, mRNA technology confronts numerous critical hurdles, including worries about mRNA enzyme degradation, permeability, vaccine stability or inflammation, autoimmune problems, and cardiovascular problems. A recent report by the Centers for Disease Control and Prevention (CDC) advisory group on vaccination policies found that there is probably a link between cardiovascular (CV) diseases and the COVID-19 mRNA vaccine. According to research from the United States, the United Kingdom, and Switzerland, myocarditis and pericarditis are the most common cardiovascular complications in teenage boys following COVID-19 mRNA vaccination. Treatment of vaccine-induced CV disorders includes corticosteroids, NSAIDs, colchicine, and, in severe cases, IVIG. Corticosteroids and percutaneous coronary intervention (PCI) with guideline-directed medical therapy (GDMT) have also been proposed to treat vaccine-induced myocarditis. Complementary and alternative medicine (CAM) may assist patients with CV disease, but physicians and patients may overlook its use.

This study aims to review the history, investigate, summarize, and simplify the understanding of the association between RNA vaccines and heart disorders.

Keywords: Autoimmune Disorders; Complementary and Alternative Medicine; Enzyme Degradation; Vaccine-Induced Disorders

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