EC Cardiology

The prospects of healthcare systems and their results may be influenced by nanotechnology. Researchers have recently become very interested in gold nanoparticles (AuNPs) because of their superior physiochemical characteristics. AuNPs exhibit size- and shape-dependent optical and electronic properties and are noncorroding, biocompatible, and amenable to the desired functionalization.

Due to their exceptional qualities, AuNPs have the potential to be used in a wide range of biomedical applications, such as optical bioimaging, targeted drug delivery (TDD), immunoassays, medicinal diagnostics, laser phototherapy of cancer cells and tumors, and genomics. AuNPs bind readily to proteins, antibodies, enzymes, and cytokines. However, particle size may affect how it is distributed throughout the body. AuNPs are FDA-approved metallic nanoparticles that have shown great promise in several medical applications.

To target cancer cells, researchers used nanogold to bind specific antibodies. AuNPs have antioxidant and anti-inflammatory properties that can help with maladies triggered by inflammation and reactive oxygen species (ROS). In addition, AuNP has been claimed to treat rheumatic, mental, neurological, bone, cartilage, cardiovascular, and skin disorders.

Moreover, AuNPs have been shown to boost immunity. This review aims to provide an overview of the historical corporal use of gold throughout the ages—to the present, how AuNPs are synthesized, how they affect human physiology, toxicity, potential positive effects, and their future applications.

Keywords: Bioimaging; Boost Immunity; Nanotechnology; Reactive Oxygen Species; Targeting Cancer Cells

1. Sebring PL. “Shining a spotlight on monatomic gold and your health”. Prime Women | An Online Magazine (2022). https://primewomen.com/health/monatomic-gold-and-your-health/
2. Bansal SA., et al. “Role of gold nanoparticles in advanced biomedical applications”. Nanoscale Advances9 (2020): 3764-3787. https://pubs.rsc.org/en/content/articlelanding/2020/na/d0na00472c
3. Arvizo R., et al. “Gold nanoparticles: opportunities and challenges in nanomedicine”. Expert Opinion on Drug Delivery6 (2010): 753-763. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874072/
4. Dykman LA and Khlebtsov NG. “Gold nanoparticles in biology and medicine: Recent advances and prospects”. Acta Naturae2 (2011): 34-55. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347577/
5. Sibuyi NRS., et al. “Multifunctional gold nanoparticles for improved diagnostic and therapeutic applications: A review”. Nanoscale Research Letters1 (2021): 174. https://pubmed.ncbi.nlm.nih.gov/34866165/
6. Zwingle E. “Gold as a rejuvenator: Myths and facts”. The Craftsmanship Initiative (2022). https://craftsmanship.net/sidebar/gold-as-a-rejuvinator-myths-and-facts/
7. Daraee H., et al. “Application of gold nanoparticles in biomedical and drug delivery”. Artificial Cells, Nanomedicine, and Biotechnology1 (2016): 410-422. https://pubmed.ncbi.nlm.nih.gov/25229833/
8. White gold essential liquid (ORMUS). The Holistic Science Co (2022). https://www.theholisticscienceco.com/white-gold-essential-liquid-ormus/
9. Gold in Ancient Egypt. Metmuseum (2022). https://www.metmuseum.org/toah/hd/egold/hd_egold.htm
10. How did gold get its name? Gold-Traders (UK) Ltd (2022). https://www.gold-traders.co.uk/gold-information/how-did-gold-get-its-name.asp
11. Columbus C. “Precious metals”. Encyclopedia (2022). https://www.encyclopedia.com/earth-and-environment/minerals-mining-and-metallurgy/metallurgy-and-mining-terms-and-concepts/precious-metals
12. Gov (2022). https://vedicheritage.gov.in/vedic-heritage-in-present-context/metallurgy/
13. Pricker SP. “Medical uses of gold compounds: Past, present and future”. Gold Bull2 (1996): 53-60. https://link.springer.com/article/10.1007/BF03215464
14. Balfourier A., et al. “Gold-based therapy: From past to present”. Proceedings of the National Academy of Sciences of the United States of America37 (2020): 22639-22648. https://www.pnas.org/doi/10.1073/pnas.2007285117
15. Nafisi S and Maibach HI. “Nanotechnology in Cosmetics”. In: Cosmetic Science and Technology Elsevier (2017): 337-369. https://www.researchgate.net/publication/314665347_Nanotechnology_in_Cosmetics
16. Khan MA., et al. “A Review on Gold Nanoparticles: Biological Synthesis, Characterizations, and Analytical Applications”. Results in Chemistry (2022). https://www.sciencedirect.com/science/article/pii/S2405653717300489
17. Chen X., et al. “Gold nanostructures for bioimaging, drug delivery and therapeutics”. In: Precious Metals for Biomedical Applications. Elsevier (2014): 163-176. https://www.sciencedirect.com/science/article/pii/B9780857094346500081
18. Giljohann DA., et al. “Gold nanoparticles for biology and medicine”. In: Spherical Nucleic Acids. Jenny Stanford Publishing (2020): 55-90. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930332/
19. Vines JB., et al. “Gold nanoparticles for photothermal cancer therapy”. Frontiers in Chemistry 7 (2019): 167. https://www.frontiersin.org/articles/10.3389/fchem.2019.00167/full
20. Khan MAR., et al. “A review on gold nanoparticles: Biological synthesis, characterizations, and analytical applications”. Results in Chemistry100478 (2022): 100478. https://www.sciencedirect.com/science/article/pii/S2405653717300489
21. Freitas De Freitas L., et al. “An overview of the synthesis of gold nanoparticles using radiation technologies”. Nanomaterials (2018): 8. https://pubmed.ncbi.nlm.nih.gov/30445694/
22. Brust M., et al. “Synthesis of thiol-derivatised gold nanoparticles in a two-phase liquid-liquid system”. Journal of the Chemical Society, Chemical Communications 7 (1994): 801-802. https://pubs.rsc.org/en/content/articlelanding/1994/c3/c39940000801
23. Herizchi R., et al. “Current methods for synthesis of gold nanoparticles”. Artificial Cells, Nanomedicine, and Biotechnology2 (2016): 596-602. https://www.tandfonline.com/doi/abs/10.3109/21691401.2014.971807
24. Li Y., et al. “Mechanistic insights into the Brust−Schiffrin two-phase synthesis of organo-chalcogenate-protected metal nanoparticles”. Journal of the American Chemical Society7 (2011): 2092-2095. https://pubs.acs.org/doi/10.1021/ja1105078
25. Madhusudanan P., et al. “Effect of gold nanoparticle treated dorsal root ganglion cells on peripheral neurite differentiation”. Toxicology in Vitro105175 (2021): 105175. https://pubmed.ncbi.nlm.nih.gov/33865945/
26. Rizvi SMD., et al. “Gold nanoparticles: A plausible tool to combat neurological bacterial infections in humans”. Biomedicine and Pharmacotherapy 107 (2018): 7-18. https://www.sciencedirect.com/science/article/pii/S0753332218326234
27. Mo J., et al. “The Nervous System Is the Major Target for Gold Nanoparticles: Evidence from RNA Sequencing Data of C. Elegans”. Bio Rxiv (2020). https://europepmc.org/article/ppr/ppr85455
28. Sonavane G., et al. “Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size”. Colloids and Surfaces B: Biointerfaces2 (2008): 274-280. https://pubmed.ncbi.nlm.nih.gov/18722754/
29. Falagan-Lotsch P., et al. “One low-dose exposure of gold nanoparticles induces long-term changes in human cells”. Proceedings of the National Academy of Sciences of the United States of America47 (2016): 13318-13323. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127334/
30. Lin YL., et al. “Sciatic nerve repair by microgrooved nerve conduits made of chitosan-gold nanocomposites”. Surgical Neurology InternationalS1 (2008): 9-18. https://pubmed.ncbi.nlm.nih.gov/18440619/
31. Zhang J., et al. “Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases”. Frontiers in Physiology (2018): 9. https://www.frontiersin.org/articles/10.3389/fphys.2018.00642/full
32. Ko WC., et al. “Pharmacological role of functionalized gold nanoparticles in disease applications”. Molecules5 (2022): 1551. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911979/
33. Söderstjerna E., et al. “Gold- and silver nanoparticles affect the growth characteristics of human embryonic neural precursor cells”. PLoS One3 (2013): e58211. https://pubmed.ncbi.nlm.nih.gov/23505470/
34. Siddiqi NJ., et al. “Identification of potential biomarkers of gold nanoparticle toxicity in rat brains”. Journal of Neuroinflammation1 (2012): 123. https://www.researchgate.net/publication/225300130_Identification_of_potential_biomarkers_of_gold_nanoparticle_toxicity_in_rat_brains
35. Carvalho-de-Souza JL., et al. “Photosensitivity of neurons enabled by cell-targeted gold nanoparticles”. Neuron1 (2015): 207-217. https://www.sciencedirect.com/science/article/pii/S0896627315001488
36. Eom K., et al. “Photothermal activation of astrocyte cells using localized surface plasmon resonance of gold nanorods”. Journal of Biophotonics4 (2017): 486-493. https://pubmed.ncbi.nlm.nih.gov/28164459/
37. Love SA., et al. “Examining changes in cellular communication in neuroendocrine cells after noble metal nanoparticle exposure”. Analyst13 (2012): 3004-3010. https://pubmed.ncbi.nlm.nih.gov/22382603/
38. Soenen SJ., et al. “Cytotoxic effects of gold nanoparticles: a multiparametric study”. ACS Nano7 (2012): 5767-5783. https://pubs.acs.org/doi/10.1021/nn301714n
39. Jung S., et al. “Intracellular gold nanoparticles increase neuronal excitability and aggravate seizure activity in the mouse brain”. PLoS One3 (2014): e91360. https://pubmed.ncbi.nlm.nih.gov/24625829/
40. Chen YS., et al. “Size-dependent impairment of cognition in mice caused by the injection of gold nanoparticles”. Nanotechnology48 (2010): 485102. https://pubmed.ncbi.nlm.nih.gov/21051801/
41. Zhang XD., et al. “Toxicologic effects of gold nanoparticles in vivo by different administration routes”. International Journal of Nanomedicine 5 (2010): 771-781. https://pubmed.ncbi.nlm.nih.gov/21042423/
42. Sun PP., et al. “Subchronic oral toxicity evaluation of gold nanoparticles in male and female mice”. Heliyon3 (2021): e06577. https://www.sciencedirect.com/science/article/pii/S2405844021006800#!
43. Gao Q., et al. “Gold nanoparticles in cancer theranostics”. Frontiers in Bioengineering and Biotechnology 9 (2021): 647905. https://www.frontiersin.org/articles/10.3389/fbioe.2021.647905/full
44. Sani A., et al. “Toxicity of gold nanoparticles (AuNPs): A review”. Biochemistry and Biophysics Reports 26 (2021): 100991. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063742/
45. Dumé I. Gold nanoparticles inside cells are not inert, say researchers – Physics World (2022).
46. Pallotta A., et al. “Quality control of gold nanoparticles as pharmaceutical ingredients”. International Journal of Pharmaceutics118583 (2019): 118583.
47. Gold nanoparticles market. Imarcgroup (2022). https://www.imarcgroup.com/gold-nanoparticles-market
48. Linan S. “Here’s a way to produce nanomaterials on a larger scale”. USC News (2022). https://news.usc.edu/92312/heres-a-way-to-produce-nanomaterials-on-a-larger-scale/
49. Adewale OB., et al. “Toxicological behavior of gold nanoparticles on various models: Influence of physicochemical properties and other factors”. International Journal of Toxicology5 (2019): 357-384. https://pubmed.ncbi.nlm.nih.gov/31462100/
50. Gerber A., et al. “Gold nanoparticles: recent aspects for human toxicology”. Journal of Occupational Medicine and Toxicology1 (2013): 32. https://occup-med.biomedcentral.com/articles/10.1186/1745-6673-8-32
51. Kim KT., et al. “Gold nanoparticles disrupt zebrafish eye development and pigmentation”. Toxicological Sciences2 (2013): 275-288. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663565/
52. Rathore M., et al. “Comparative in vivo assessment of the subacute toxicity of gold and silver nanoparticles”. Journal of Nanoparticle Research4 (2014): 1-2. https://link.springer.com/article/10.1007/s11051-014-2338-x
53. Alkilany AM and Murphy CJ. “Toxicity and cellular uptake of gold nanoparticles: What we have learned so far. In: Nanomaterials and Neoplasms”. Jenny Stanford Publishing (2021): 657-698. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988217/
54. Sengupta J., et al. “In vivo interaction of gold nanoparticles after acute and chronic exposures in experimental animal models”. Journal of Nanoscience and Nanotechnology3 (2013): 1660-1670. https://pubmed.ncbi.nlm.nih.gov/23755571/
55. Goodman CM., et al. Toxicity of Gold Nanoparticles Functionalized wif Cationic and Anionic Side Chains 15 (2004): 897-900. https://pubs.acs.org/doi/10.1021/bc049951i
56. Xia Q., et al. “The effect of particle size on the genotoxicity of gold nanoparticles”. Journal of Biomedical Materials Research Part A3 (2017): 710-719. https://pubmed.ncbi.nlm.nih.gov/27770565/
57. Liu Y., et al. “The effects of gold nanoparticles on Leydig cells and male reproductive function in mice”. International Journal of Nanomedicine 15 (2020): 9499-9514. https://www.researchgate.net/publication/342966334_The_effects_of_gold_nanoparticles_on_Leydig_cells_and_male_reproductive_function_in_mice
58. Kumar H., et al. “Applications of nanotechnology in sensor-based detection of foodborne pathogens”. Sensors7 (2020): 1966. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181077/
59. Hammami I., et al. “Gold nanoparticles: Synthesis properties and applications”. Journal of King Saud University Science7 (2021): 101560. https://www.sciencedirect.com/science/article/pii/S1018364721002214
60. Sharma N., et al. “Gold Nanoparticles synthesis, properties, and forthcoming applications : A review”. Indian Journal of Pharmaceutical and Biological Research02 (2015): 13-27. https://www.researchgate.net/publication/325185846_Gold_Nanoparticles_synthesis_properties_and_forthcoming_applications_A_review
61. Bai X., et al. “The basic properties of gold nanoparticles and their applications in tumor diagnosis and treatment”. International Journal of Molecular Sciences7 (2020): 2480. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178173/