EC Cardiology

Cardiovascular diseases (CVD) are a heterogeneous group of disorders that affect the heart and blood vessels. According to the World Health Organization in 2019, 17.9 millions of deaths were due to coronary heart disease and it is projected that by 2030 almost 23.6 million people will die from CVD. Myocardial infarction is a death of a segment of heart muscle, which follows interruption of its blood supply. During myocardial infarction, there is huge generation of various reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, and hydroxyl radicals. Many epidemiological studies have suggested that myocardial infarction is one of the greatest risk factors for morbidity and mortality [1]. The animal models of myocardial infarction are essential to understand the prevention, diagnosis and management of human myocardial infarction.

1. Sharmila Queenthy S and John Babu. “Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats”. European Journal of Pharmacology1-3 (2013): 213-218.
2. S Sharmila Queenthy., et al. “Diosmin prevents left ventricular hypertrophy, adenosine triphosphatases dysfunction and electrolyte imbalance in experimentally induced myocardial infarcted rats”. European Journal of Pharmacology 814 (2017): 124-129.
3. S Sharmila Queenthy., et al. “Diosmin Prevents Isoproterenol-Induced Heart Mitochondrial Oxidative Stress in Rats”. Cardiovascular Toxicology2 (2018): 120-130.