EC Clinical and Medical Case Reports

Castleman disease (CD), referred to as giant lymph node hyperplasia, is a rare lymphoproliferative disorder initially documented by Dr. Benjamin Castleman in 1954. Diagnosis poses a challenge due to its variable clinical presentations and the absence of distinct radiological characteristics. CD can present as either localized (unicentric) or systemic (multicentric), exhibiting diverse histopathological subtypes.

Here we report a new case of unicentric Castleman's disease in the posterior mediastinum presenting with dyspnea and shortness of breath.

 Keywords: Castleman Disease; Castleman Syndrome; Unicentric Castleman’s Disease; Multicentric Castleman’s Disease; Lymphoproliferative Disorder

1. Chen H., et al. “Case Report: A rare case of primary hepatic Castleman’s disease mimicking a liver tumor”. Frontiers in Oncology 12 (2022): 974263.
2. Castleman B and Towne VW. “Case records of the Massachusetts General Hospital weekly clinicopathological exercises founded by Richard C. Cabot”. New England Journal of Medicine 10 (1954): 396-400.
3. Saadallah MAH. “Castleman's disease: A rare case report and review of literature”. International Journal of Surgery Case Reports 95 (2022): 107282.
4. Oksenhendler E., et al. “The full spectrum of Castleman disease: 273 patients studied over 20 years”. British Journal of Haematology2 (2018): 206-216.
5. Dispenzieri A and Fajgenbaum DC. “Overview of Castleman disease”. Blood16 (2020): 1353-1364.
6. Hong Chen., et al. “A rare case of primary hepatic Castleman’s disease mimicking a liver tumor”. Frontiers in Oncology 12 (2022): 974263.
7. Nadir A., et al. “Isolated intrapulmonary Castleman's disease: a case report, review of the literature”. Annals of Thoracic and Cardiovascular Surgery 20 (2014): 689-691.
8. Gündüz E., et al. “A Rare Lymphoproliferative Disease: Castleman Disease”. Turkish Journal of Hematology 4 (2021): 314-320.
9. Christian Hoffmann., et al. “Recent Advances in Castleman Disease”. Oncology Research and Treatment 11 (2022): 693-704.
10. Saeed-Abdul-Rahman I and Al-Amri AM. “Castleman disease”. Korean Journal of Hematology 3 (2012): 163-177.
11. Shetty S., et al. “Video assisted thoracoscopic resection of a posterior mediastinal Castleman's tumor”. Journal of Cardiothoracic Surgery 6 (2011): 113.