EC Clinical and Medical Case Reports

Review Article Volume 6 Issue 7 - 2023

The Role of Salus Per Aquam (Spa) Therapy in Specific, Systemic Conditions and Disorders

Sudeep Chawla1†, Nicholas A Kerna2,3*†, Ogochukwu Mirian Akuma4, Cornelius I Azi1, John V Flores6, Dabeluchi C Ngwu7,8, Kevin D Pruitt9,10, ND Victor Carsrud11 and Hilary M Holets6

1Chawla Health & Research, USA

2Independent Global Medical Researchers Consortium

3First InterHealth Group, Thailand

4Saint Nicholas Hospital, Lagos Nigeria

5Northern Care Alliance NHS Foundation Trust, UK

6Orange Partners Surgicenter, USA

7Cardiovascular and Thoracic Surgery Unit, Department of Surgery, Federal Medical Center, Umuahia, Nigeria

8Earthwide Surgical Missions, Nigeria

9Kemet Medical Consultants, USA

10PBJ Medical Associates, LLC, USA

11Lakeline Wellness Center, USA

*Corresponding Author: Nicholas A Kerna, (mailing address) POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500. Contact: medpublab+drkerna@gmail.com † indicates co-first author
Received: June 02, 2023; Published: July 21, 2023



Salus per Aquam (Spa) therapy (or medicine) uses “healing” waters as part of its treatment regimen—in particular, sulfate mineral water (containing predominantly sulfate anion SO42−). The therapy generally incorporates hydrotherapy, therapeutic drinks, medical massage, water jet massage, bathing, and physical therapy in thermal water. Over many centuries, countries have used spa therapy to treat various diseases and promote overall wellness. The mechanisms by which broad spectrums of diseases respond to spa therapy incorporate chemical, thermal, and mechanical effects. Spa mineral waters are chemically classified as sulfurous, sulfate, arsenical-ferruginous, and bicarbonate. Clinical treatment typically uses sulfate mineral waters with sulfate anion SO42- as the predominant element. Spa therapy techniques primarily prevent, treat, and rehabilitate musculoskeletal conditions. However, they have also shown promise for several other indications, including treating or rehabilitating dermatological, immuno-inflammatory, chronic pain syndrome, cardiac, metabolic, and neurological diseases. Here, we describe the antioxidant and therapeutic role of thermal or spa mineral water in specific health conditions and disorders and its improvement of quality of life (QoL).

Keywords: Cardiovascular Disorders; Chronic Pain Syndrome; Medical Mineral Water; Natural Remedies for Skin Conditions; Physical Therapy; Sulfate Mineral Water

  1. Capellini S. “The complete spa book for massage therapists”. Cengage Learning (2023). https://www.academia.edu/27281211/Complete_Spa_Book_for_Massage_Therapists
  2. Van Tubergen A and van der Linden S. “A brief history of spa therapy”. Annals of the Rheumatic Diseases3 (2002): 273-275. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1754027/
  3. Cacciapuoti S., et al. “Teh Role of Thermal Water in Chronic Skin Diseases Management: A Review of teh Literature”. Journal of Clinical Medicine9 (2020). https://pubmed.ncbi.nlm.nih.gov/32971735/
  4. Melillo L. “Medicina nei secoli”. Journal of History of Medicine and Medical Humanities 7 (1995): 461-483. https://rosa.uniroma1.it/rosa01/medicina_nei_secoli/
  5. Sinha A. “History of spa and its origins!”. Spa Nation (2023). https://www.spanation.net/post/history-of-spa-and-its-origins
  6. Gianfaldoni S., et al. “History of the baths and Thermal Medicine”. Open Access Macedonian Journal of Medical Sciences4 (2017): 566-568. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535692/
  7. Jackson R. “Waters and spas in the classical world”. Medical History. Supplement 10 (1990): 1-13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557448/
  8. Routh HB., et al. “Balneology, mineral water, and spas in historical perspective”. Clinics in Dermatology6 (1996): 551-554. https://pubmed.ncbi.nlm.nih.gov/8960791/
  9. Palmer R. “In this our lightye and learned tyme”: Italian baths in the era of the Renaissance”. Medical History. Supplement 10 (1990): 14-22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557455/
  10. Brockliss LW. “The development of the spa in seventeenth-century France”. Medical History. Supplement 10 (1990): 23-47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557450/
  11. Skopec M. “Vincent Priessnitz and the Vienna Medical School”. Wiener klinische Wochenschrift16 (1991): 506-508. https://pubmed.ncbi.nlm.nih.gov/1949807/
  12. Cavanah C. “Guide to Hydrothermal Spa and Wellness Development Standards What You Need to Know Before Building Wet Areas”. Miami: Global Wellness Institute (2016): 27. https://globalwellnessinstitute.org/wp-content/uploads/2019/12/GWI_Hydrothermal_2018_US-final-updated_1125191.pdf
  13. Grossi F. “Parks and hydro-mineral springs in the classical world and in the contemporary era. Place in therapeutics”. Clinical Therapeutics11 (1997): 549-565. https://pubmed.ncbi.nlm.nih.gov/9494258/
  14. Suárez M., et al. “Identification of organic compounds in San Diego de los Baños Peloid (Pinar del Río, Cuba)”. Journal of Alternative and Complementary Medicine2 (2011): 155-165. https://pubmed.ncbi.nlm.nih.gov/21309710/
  15. Borroni G., et al. “Clinical, pathological and immunohistochemical effects of arsenical-ferruginous spa waters on mild-to-moderate psoriatic lesions: a randomized placebo-controlled study”. International Journal of Immunopathology and Pharmacology2 (2013): 495-501. https://pubmed.ncbi.nlm.nih.gov/23755765/
  16. Paoloni M., et al. “Appropriateness and efficacy of Spa therapy for musculoskeletal disorders. A Delphi method consensus initiative among experts in Italy”. Annali dell'Istituto Superiore di Sanità1 (2017): 70-76. https://pubmed.ncbi.nlm.nih.gov/28361808/
  17. Costantino M., et al. “Sulfate mineral waters: A medical resource in several disorders”. Journal of Traditional and Complementary Medicine4 (2020): 320-326. https://pubmed.ncbi.nlm.nih.gov/32695648/
  18. Riyaz N and Arakkal FR. “Spa therapy in dermatology”. Indian Journal of Dermatology, Venereology and Leprology2 (2011): 128-134. https://pubmed.ncbi.nlm.nih.gov/21393940/
  19. Antonelli M., et al. “Clinical efficacy of medical hydrology: an umbrella review”. International Journal of Biometeorology10 (2021): 1597-1614. https://pubmed.ncbi.nlm.nih.gov/33866427/
  20. Crebbin-Bailey J., et al. “The Spa Book: The official guide to spa therapy”. Cengage Learning EMEA (2005).
  21. Nasermoaddeli A and Kagamimori S. “Balneotherapy in medicine: A review”. Environmental Health and Preventive Medicine4 (2005): 171-179. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723310/
  22. Ohare JP., et al. “Observations on the effect of immersion in bath spa water”. British Medical Journal 291 (1985): 1747-1751. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1419186/
  23. Adler E. “Some clinical experiences with the springs at Zohar on the shore of the Dead Sea”. Israel Medical Association Journal 20 (1961): 304-308. https://pubmed.ncbi.nlm.nih.gov/13859436/
  24. Smith JB., et al. “Human lymphocyte responses are enhanced by culture at 40°C”. Journal of Immunology2 (1978): 691-694. https://journals.aai.org/jimmunol/article-abstract/121/2/691/10673/Human-Lymphocyte-Responses-Are-Enhanced-by-Culture?redirectedFrom=PDF
  25. Valeriani F., et al. “Recreational use of spa thermal waters: Criticisms and perspectives for innovative treatments”. International Journal of Environmental Research and Public Health12 (2018): 2675. https://www.researchgate.net/publication/329264851_Recreational_Use_of_Spa_Thermal_Waters_Criticisms_and_Perspectives_for_Innovative_Treatments
  26. Crespo PV., et al. “Efects of sodium chloride-rich mineral water on intestinal epithelium. Experimental Study”. International Journal of Environmental Research and Public Health (2021): 18. https://pubmed.ncbi.nlm.nih.gov/33809886/
  27. Cacciapuoti S., et al. “The role of thermal water in chronic skin diseases management: A review of the literature”. Journal of Clinical Medicine9 (2020): 3047. https://pubmed.ncbi.nlm.nih.gov/32971735/
  28. Costantino M., et al. “Filippelli Sulfurous Mud balneotherapy: an possible strategy for de plaque psoriasis”. Paripex - Indian Journal of Research3 (2015): 69-e74. https://www.researchgate.net/publication/281289652_Sulphurous_Mud-Balneotherapy_an_Possible_Strategy_for_the_Plaque_Psoriasis
  29. Razumov AN., et al. “Therapeutic and preventive effects of sulfate-chloride-sodium mineral water in experimental peptic ulcer Vopr Kurortol Fizioter Lech”. The Voprosy Kurortologii, Fizioterapii, I Lechebnoi Fizicheskoi Kultury 3 (2009): 22-e25. https://pubmed.ncbi.nlm.nih.gov/19639693/
  30. Mooventhan A and Nivethitha L. “Scientific evidence-based effects of hydrotherapy on various systems of the body N”. The American Journal of the Medical Sciences5 (2014): 199-e209. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049052/
  31. Gasbarrini G., et al. “Evaluation of thermal water in patients with functional dyspepsia and irritable bowel syndrome accompanying constipation”. World Journal of Gastroenterology16 (2006): 2556-2562. https://pubmed.ncbi.nlm.nih.gov/16688801/
  32. Corsini A., et al. “Effects of spa treatment on cardiac autonomic control at rest in healthy subjects”. Sport Sciences for Health2 (2015): 181-186. https://link.springer.com/article/10.1007/s11332-015-0221-5
  33. Wellness and Mental Health Benefits of Spa Therapy. Spa Industry Association (2023). https://dayspaassociation.com/wellness-and-mental-health-benefits-of-spa-therapy/
  34. Shin TW., et al. “Are hot tubs safe for people with treated hypertension?” Canadian Medical Association Journal12 (2003): 1265-1268. https://pubmed.ncbi.nlm.nih.gov/14662661/
  35. Hot baths and saunas: Beneficial for your heart? Harvard Health (2023). https://www.health.harvard.edu/heart-health/hot-baths-and-saunas-beneficial-for-your-heart
  36. Petraccia L. “The possible uses of balneotherapy in treating chronic venous insufficiency of lower limbs”. Clinical Therapeutics3 (2013): 233-238. https://pubmed.ncbi.nlm.nih.gov/23868626/
  37. Oyama JI., et al. “Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure”. Heart Vessels2 (2013): 173-178. https://pubmed.ncbi.nlm.nih.gov/22231540/
  38. Sun HJ., et al. “Role of endothelial dysfunction in cardiovascular diseases: The link between inflammation and hydrogen sulfide”. Frontiers in Pharmacology 10 (2019): 1568. https://pubmed.ncbi.nlm.nih.gov/32038245/
  39. Karaarslan F., et al. “How does spa treatment effect cardiovascular function and vascular endothelium in patients with generalized osteoarthritis? A pilot study through plasma asymmetric di-methyl arginine (ADMA) and L-arginine/ADMA ratio”. International Journal of Biometeorology (2017). https://pubmed.ncbi.nlm.nih.gov/29218448/
  40. Leibetseder V., et al. “Improving homocysteine levels through balneotherapy: effects of sulfur baths”. Clinica Chimica Acta1-2 (2004): 105-111. https://pubmed.ncbi.nlm.nih.gov/15115681/
  41. Ozkan Y., et al. “Plasma total homocysteine and cysteine levels as cardiovascular risk factors in coronary heart disease”. International Journal of Cardiology3 (2002): 269-277. https://pubmed.ncbi.nlm.nih.gov/11911915/
  42. Lee D., et al. “Effects on static and dynamic balance of task-oriented training for patients in water or on land”. The Journal of Physical Therapy Science3 (2010): 331-336. https://www.jstage.jst.go.jp/article/jpts/22/3/22_3_331/_pdf
  43. Mehrholz J., et al. “Water-based exercises for improving activities of daily living after stroke”. Cochrane Database of Systematic Reviews 1 (2011): CD008186. https://pubmed.ncbi.nlm.nih.gov/21249701/
  44. Jiang L., et al. “Magnesium levels in drinking water and coronary heart disease mortality risk: A meta-analysis”. Nutrients1 (2016): 5. https://pubmed.ncbi.nlm.nih.gov/26729158/
  45. Ohtsuka Y., et al. “Effect of thermal stress on glutathione metabolism in human erythrocytes”. European Journal of Applied Physiology and Occupational Physiology1 (1994): 87-91. https://link.springer.com/article/10.1007/BF00599247
  46. Gálvez I., et al. “Balneotherapy, immune system, and stress response: A hormetic strategy?” International Journal of Molecular Sciences6 (2018): 1687. https://pubmed.ncbi.nlm.nih.gov/29882782/
  47. Ohtsuka Y., et al. “Balneotherapy and platelet glutathione metabolism in type II diabetic patients”. International Journal of Biometeorology3 (1996): 156-159. https://pubmed.ncbi.nlm.nih.gov/8937270/
  48. Strauss-Blasche G., et al. “Seasonal variation of lipid-lowering effects of complex spa therapy”. Forsch Komplementarmed Klass Naturheilkd2 (2003): 78-84. https://pubmed.ncbi.nlm.nih.gov/12808366/
  49. Cristina Maria., et al. “Drinking mineral waters: biochemical effects and health implications - the state of the art”. International Journal of Environmental Health Research154 (2007): 153-e169. https://www.researchgate.net/publication/228469193_Drinking_mineral_waters_Biochemical_effects_and_health_implications_-_The_state-of-the-art
  50. Cantalamessa F and Nasuti C. “Hypocholesterolemic activity of calcic and magnesic sulfate-sulfurous spring mineral water in the rat”. Nutrition Research 23 (2003): 775-e789. https://www.sciencedirect.com/science/article/abs/pii/S0271531703000332
  51. Albertini MC., et al. “Drinking mineral waters: biochemical effects and health implications the state-of-the-art”. International Journal of Environmental Health Research1 (2007): 153. https://www.inderscience.com/info/inarticle.php?artid=12230
  52. Dupont C., et al. “Efficacy and safety of a magnesium sulfaterich natural mineral water for patients with functional constipation”. Clinical Gastroenterology and Hepatology8 (2014): 1280-e1287. https://pubmed.ncbi.nlm.nih.gov/24342746/
  53. Ikarashi N., et al. “A mechanism by which the osmotic laxative magnesium sulfate increases the intestinal aquaporin 3 expression in HT-29 cells”. Life Sciences3-4 (2011): 194-200. https://pubmed.ncbi.nlm.nih.gov/21094173/
  54. Bothe G., et al. “Efficacy and safety of a natural mineral water rich in magnesium and sulfate for bowel function: a double-blind, randomized, placebo-controlled study”. European Journal of Nutrition2 (2017): 491-499. https://pubmed.ncbi.nlm.nih.gov/26582579/
  55. Casado Á., et al. “Types and characteristics of drinking water for hydration in the elderly”. Critical Reviews in Food Science and Nutrition12 (2015): 1633-1641. https://pubmed.ncbi.nlm.nih.gov/24915336/
  56. Quattrini S., et al. “Natural mineral waters: chemical characteristics and health effects”. Clinical Cases in Mineral and Bone Metabolism3 (2016): 173-180. https://pubmed.ncbi.nlm.nih.gov/28228777/
  57. Fortunati NA., et al. “May spa therapy be a valid opportunity to treat hand osteoarthritis? A review of clinical trials and mechanisms of action”. International Journal of Biometeorology1 (2016): 1-8. https://pubmed.ncbi.nlm.nih.gov/26156832/
  58. Scalabrino A., et al. “A single mud-bath treatment induces increased levels of circulating endogeneous opioids”. Current3 (1994): 5-e10.
  59. Forestier R., et al. “Spa therapy in the treatment of knee osteoarthritis: a large randomized multicentre trial”. Annals of the Rheumatic Diseases4 (2010): 660-665. https://pubmed.ncbi.nlm.nih.gov/19734131/
  60. Bhateja S., et al. Balneotherapy in Medicine and Dentistry: A Review (2019). https://www.jsas.co.in/article-details/8829
  61. Pittler MH., et al. “Spa therapy and balneotherapy for treating low back pain: meta-analysis of randomized trials”. Rheumatology7 (2006): 880-884. https://pubmed.ncbi.nlm.nih.gov/16449365/
  62. Sukenik S., et al. “Balneotherapy for rheumatoid arthritis at the Dead Sea”. Israel Medical Association Journal4 (1995): 210-214. https://pubmed.ncbi.nlm.nih.gov/7721556/
  63. McVeigh JG., et al. “The effectiveness of hydrotherapy in the management of fibromyalgia syndrome: a systematic review”. Rheumatology International2 (2008): 119-130. https://pubmed.ncbi.nlm.nih.gov/18751709/
  64. Fraioli A., et al. “Clinical researches on the efficacy of spa therapy in fibromyalgia. A systematic review”. Annali dell'Istituto Superiore di Sanità2 (2013): 219-229. https://pubmed.ncbi.nlm.nih.gov/23771266/
  65. Maccarone MC and Masiero S. “Spa therapy interventions for post respiratory rehabilitation in COVID-19 subjects: does the review of recent evidence suggest a role?” Environmental Science and Pollution Research International33 (2021): 46063-46066. https://pubmed.ncbi.nlm.nih.gov/34273080/
  66. Maccarone MC., et al. “From in vitro research to real life studies: an extensive narrative review of the effects of balneotherapy on human immune response”. Sport Sciences for Health4 (2021): 817-835. https://pubmed.ncbi.nlm.nih.gov/34035862/
  67. Corradi M., et al. “Effect of salt-bromide-iodine thermal water inhalation on functional and biochemical lung parameters”. ISRN Pulmonology (2012): 1-8. https://www.hindawi.com/journals/isrn/2012/534290/
  68. Khaltaev N., et al. “Balneotherapy and hydrotherapy in chronic respiratory disease”. Journal of Thoracic Disease8 (2020): 4459-4468. https://pubmed.ncbi.nlm.nih.gov/32944359/
  69. Cohen M. “Turning up the heat on COVID-19: heat as a therapeutic intervention”. F1000Research 9 (2020): 292. https://pubmed.ncbi.nlm.nih.gov/32742639/
  70. Masiero S., et al. “Balneotherapy and human immune function in the era of COVID-19”. International Journal of Biometeorology8 (2020): 1433-1434. https://pubmed.ncbi.nlm.nih.gov/32300868/
  71. Keller S., et al. “Thermal water applications in the treatment of upper respiratory tract diseases: a systematic review and meta-analysis”. Journal of Allergy (2014): 943824. https://pubmed.ncbi.nlm.nih.gov/24987423/
  72. Cantone E., et al. “Nasal cytological assessment after crenotherapy in the treatment of chronic rhinosinusitis in the elderly”. International Journal of Immunopathology and Pharmacology4 (2014): 683-687. https://pubmed.ncbi.nlm.nih.gov/25572751/
  73. Passariello A., et al. “Crenotherapy modulates the expression of pro-inflammatory cytokines and immunoregulatory peptides in nasal secretions of children with chronic rhinosinusitis”. The American Journal of Rhinology and Allergy1 (2012): e15-e19. https://pubmed.ncbi.nlm.nih.gov/22391070/
  74. Evgenev MB and Frenkel A. “Possible application of H2S-producing compounds in therapy of coronavirus (COVID-19) infection and pneumonia”. Cell Stress Chaperones 25 (2020): 713-715. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221330/
  75. Bailly M., et al. “Health management of patients with COVID-19: is there a room for hydrotherapeutic approaches?” International Journal of Biometeorology5 (2022): 1031-1038. https://pubmed.ncbi.nlm.nih.gov/35079866/
  76. Pozzi G., et al. “Hydrogen sulfide inhibits TMPRSS2 in human airway epithelial cells: Implications for SARS-CoV-2 infection”. Biomedicines9 (2021): 1273. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469712/
  77. Li Y and Zheng G. “The efficacy of aquatic therapy in stroke rehabilitation: A protocol for systematic review and meta-analysis”. Medicine48 (2021): e27825. https://pubmed.ncbi.nlm.nih.gov/35049184/
  78. Bayraktar D., et al. “Effects of Ai-Chi on balance, functional mobility, strength and fatigue in patients with multiple sclerosis: a pilot study”. Neurological Rehabilitation3 (2013): 431-437. https://pubmed.ncbi.nlm.nih.gov/23949074/
  79. Montagna JC., et al. “Effects of aquatic physiotherapy on the improvement of balance and corporal symmetry in stroke survivors”. International Journal of Clinical and Experimental Medicine4 (2014): 1182-1187. https://pubmed.ncbi.nlm.nih.gov/24955206/
  80. Salem Y., et al. “Community-based group aquatic programme for individuals with multiple sclerosis: a pilot study”. Disability and Rehabilitation9 (2011): 720-728. https://pubmed.ncbi.nlm.nih.gov/20726740/
  81. Salem Y., et al. “Effects of an aquatic exercise program on functional mobility in individuals with multiple sclerosis: a community-based study”. The Journal of Aquatic Physical Therapy 18 (2010): 22-32. https://www.researchgate.net/publication/285518805_Effects_of_an_aquatic_exercise_program_on_functional_mobility_in_individuals_with_multiple_sclerosis_A_community-based_study
  82. De Andrade C., et al. “Efeitos da hidroterapia no equilíbrio de indivíduos com doença de Parkinson”. ConScientiae Saúde 9 (2010): 317-323. https://periodicos.uninove.br/saude/article/view/2108
  83. Useros-Olmo AI and Collado-Vázquez S. “Efectos de un programa de hidroterapia en el tratamiento de la distonía cervical. Estudio piloto”. Revue Neurologique Journal 51 (2010): 669-676. https://pesquisa.bvsalud.org/portal/resource/pt/ibc-86943
  84. Noh DK., et al. “The effect of aquatic therapy on postural balance and muscle strength in stroke survivors--a randomized controlled pilot trial”. Clinical Rehabilitation10-11 (2008): 966-976. https://www.researchgate.net/publication/23423208_The_effect_of_aquatic_therapy_on_postural_balance_and_muscle_strength_in_stroke_survivors_-_A_randomized_controlled_pilot_trial
  85. Pérez-de la Cruz S. “Comparison of aquatic therapy vs. Dry land therapy to improve mobility of chronic stroke patients”. International Journal of Environmental Research and Public Health13 (2020): 4728. https://pubmed.ncbi.nlm.nih.gov/32630188/
  86. Di Marco R., et al. “Effect of intensive rehabilitation program in thermal water on a group of people with Parkinson’s Disease: A retrospective longitudinal study”. Health Care2 (2022): 368. https://www.researchgate.net/publication/358607975_Effect_of_Intensive_Rehabilitation_Program_in_Thermal_Water_on_a_Group_of_People_with_Parkinson%27s_Disease_A_Retrospective_Longitudinal_Study
  87. Rodríguez P., et al. “Efecto del ejercicio acuático sobre la cinemática del patrón de marcha en pacientes con enfermedad de Parkinson: un estudio piloto”. Revue Neurologique Journal06 (2013): 315. https://neurologia.com/articulo/2012572
  88. Da Silva M., et al. “Effects of swimming on the functional independence of patients with spinal cord injury”. Revista Brasileira de Medicina do Esporte 11 (2005): 237-241. https://www.scielo.br/j/rbme/a/nx8VXbvRGLcnZVjHZXZZvFk/?format=pdf&lang=en
  89. Berger L., et al. “Evaluation of the immediate and midterm effects of mobilization in hot spa water on static and dynamic balance in elderly subjects”. Annales de Réadaptation et de Médecine Physique Journal2 (2008): 84-95. https://pubmed.ncbi.nlm.nih.gov/18191267/
  90. Cacciapuoti S., et al. “The Role of Thermal Water in Chronic Skin Diseases Management: A Review of the Literature”. Journal of Clinical Medicine9 (2020): 3047. https://pubmed.ncbi.nlm.nih.gov/32971735/
  91. Locksley RM., et al. “The TNF and TNF receptor superfamilies: integrating mammalian biology”. Cell4 (2001): 487-501. https://pubmed.ncbi.nlm.nih.gov/11239407/
  92. Joly F., et al. “Thermal Water from Uriage-les-Bains Exerts DNA Protection, Induction of Catalase Activity and Claudin-6 Expression on UV Irradiated Human Skin in Addition to Its Own Antioxidant Properties Journal of Cosmetics”. Journal of Dermatological Science 4 (2014): 99-e106. https://www.scirp.org/journal/paperinformation.aspx?paperid=44295
  93. Sikar Aktürk A., et al. “Nitric oxide and malondialdehyde levels in plasma and tissue of psoriasis patients: Nitric oxide and malondialdehyde levels in psoriasis”. Journal of the European Academy of Dermatology and Venereology7 (2012): 833-837. https://pubmed.ncbi.nlm.nih.gov/21749467/
  94. Kadam DP., et al. “Role of oxidative stress in various stages of psoriasis”. Indian Journal of Clinical Biochemistry4 (2010): 388-392. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994563/
  95. Nappi G., et al. “Free radical variation with mud-bath therapy by San pellegrino SPA (Italy)”. Journal of Clinical Medicine 56 (2005): 8-e18. https://www.researchgate.net/publication/288140424_Antioxidant_action_of_S_Pellegrino_mineral_water
  96. Tsoureli-Nikita E., et al. “Alternative treatment of psoriasis with balneotherapy using Leopoldine spa water”. Journal of the European Academy of Dermatology and Venereology3 (2002): 260-262. https://pubmed.ncbi.nlm.nih.gov/12195567/
  97. Beylot-Barry M., et al. “Evaluation of the benefit of thermal spa therapy in plaque psoriasis: the PSOTHERMES randomized clinical trial”. International Journal of Biometeorology6 (2022): 1247-1256. https://pubmed.ncbi.nlm.nih.gov/35347400/
  98. Lee YB., et al. “Immunomodulatory effects of balneotherapy with hae-un-dae thermal water on imiquimod-induced psoriasis-like murine model”. Annals of Dermatology2 (2014): 221-230. https://pubmed.ncbi.nlm.nih.gov/24882978/
  99. Faga A., et al. “Effects of thermal water on skin regeneration”. International Journal of Molecular Medicine5 (2012): 732-740. https://www.researchgate.net/publication/221842049_Effects_of_thermal_water_on_skin_regeneration
  100. Casas C., et al. “Modulation of Interleukin-8 and staphylococcal flora by Avène hydrotherapy in patients suffering from chronic inflammatory dermatoses: Avène hydrotherapy effects on inflammatory dermatoses”. Journal of the European Academy of Dermatology and Venereology1 (2011): 19-23. https://pubmed.ncbi.nlm.nih.gov/21175870/
  101. Aguwa US., et al. “Effect of warm water bathe on the testes and sperm quality of adult Wistar rats”. Journal of Complementary and Alternative Medical Research (2022): 51-57. https://www.researchgate.net/publication/363008628_Effect_of_Warm_Water_Bathe_on_the_Testes_and_Sperm_Quality_of_Adult_Wistar_Rats
  102. Pawlik-Sobecka L., et al. “Balneotherapy with the use of radon–sulphide water: The mechanisms of therapeutic effect”. Applied Sciences6 (2021): 2849. https://www.researchgate.net/publication/350326148_Balneotherapy_with_the_Use_of_Radon-Sulphide_Water_The_Mechanisms_of_Therapeutic_Effect
  103. Dawson PA., et al. “Sulfate in pregnancy”. Nutrients3 (2015): 1594-1606. https://pubmed.ncbi.nlm.nih.gov/25746011/
  104. Quattrini S., et al. “Natural mineral waters: chemical characteristics and health effects”. Clinical Cases in Mineral and Bone Metabolism3 (2016): 173-180. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318167/
  105. Recreational Water Illnesses. Google Books (2023). https://www.researchgate.net/publication/236836678_Recreational_Water-Related_Illness_Office_Management_and_Prevention
  106. The Risks of Spa Treatments. WebMD (2023). https://www.webmd.com/beauty/features/risks-of-spa-treatments
  107. Bai R., et al. “Effectiveness of spa therapy for patients with chronic low back pain: An updated systematic review and meta-analysis”. Medicine37 (2019): e17092. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750337/
  108. Forestier R., et al. “Current role for spa therapy in rheumatology”. Joint Bone Spine1 (2017): 9-13. https://pubmed.ncbi.nlm.nih.gov/27282090/

Nicholas A Kerna., et al. "The Role of Salus Per Aquam (Spa) Therapy in Specific, Systemic Conditions and Disorders." EC Clinical and Medical Case Reports   6.7 (2023): 01-20.