EC Clinical and Medical Case Reports

The immunomodulatory drug Thymogen (EW peptide) regulates the reactions of cellular, humoral immunity and nonspecific resistance of the body. The EW peptide was previously shown to be effective in the repair of lower extremity ulcers in patients with diabetes mellitus. This correlated with the normalization of the HIF1α protein concentration in blood plasma. The aim of this work is to elucidate the molecular mechanism of the EW peptide’s effect on the synthesis of HIF1α. Molecular modeling and ligand docking methods were used to demonstrate the possibility of binding the EW peptide to the double-stranded DNA sequences GGAG, AGGA, CCGG, GGTG, AGTC in various HIF1α gene promoters. These data suggest that the clinical efficacy of the EW peptide in diabetic foot patients is due to its ability to regulate gene expression and HIF1α protein synthesis.

Keywords: EW Peptide; HIF1α; Hypoxia; Diabetes Mellitus; Diabetic Foot

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