EC Clinical and Medical Case Reports

Cyclopia is a very rare congenital malformation characterized by the absence of separation of the two eye sockets. This anomaly is due to an embryonic developmental defect known as holoprosencephaly. Causes include trisomy 13, exposure to toxins and drugs during pregnancy, and genetic mutations. Diagnosis can be made by ultrasound in the 1st trimester. The prognosis is unfavorable, and there is no curative treatment. Management consists solely of palliative care. We report a case of cyclopia in a female newborn. The mother did not attend any prenatal consultations. Questioning revealed no consanguinitý of the newborn’s parents. No malformations in the siblings. At birth examination of the newborn revealed a malformation of the face with a single large eye in the middle of the forehead and a total absence of the nose and orbits evoking the diagnosis of cyclopia. The newborn died 14 minutes after birth. No further exploration with a view to etiology could be carried out because of the parents’ refusal.