EC Clinical and Medical Case Reports

Pituitary stalk interruption syndrome is a rare malformation characterized by a triad of aplasia or hypoplasia of the anterior pituitary, a thin or absent pituitary stalk, and ectopic posterior pituitary observed on magnetic resonance imaging. It is a major cause of hypopituitarism, particularly growth hormone deficiency leading to growth retardation. The insidious progression of the disease explains why the diagnosis is often made in the late phase. We present the case of an 11-year-old child presenting with growth retardation, whose hormonal assessment revealed complete hypopituitarism. Magnetic resonance imaging showed interruption of the pituitary stalk with ectopic posterior pituitary and hypoplastic anterior pituitary. Through this case, we describe the clinical, biological presentation, and MRI findings of pituitary stalk interruption syndrome. We emphasize the need for early diagnosis of growth retardation and timely hormonal replacement therapy to improve prognosis.

Keywords: Pituitary Stalk Interruption Syndrome (PSIS); Hypopituitarism; Growth Retardation; Ectopic Posterior Pituitary

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