EC Clinical and Medical Case Reports

Review Article Volume 9 Issue 6 - 2026

Relationship of Glymphatic System to Sleep and Neurodegenerative Disorders

Hee Boon Ng1,2 and Maurice HT Ling2,3,4*

1School of Health and Life Sciences, Teesside University, UK
2Management Development Institute of Singapore, Singapore
3Newcastle Australia Institute of Higher Education, University of Newcastle, Australia
4HOHY PTE LTD, Singapore

*Corresponding Author: Maurice HT Ling, Newcastle Australia Institute of Higher Education, University of Newcastle, Australia.
Received:August 06, 2026; Published: September 21, 2026



Neurodegenerative disorders; such as, Alzheimer’s and Parkinson’s diseases; are a pressing public health concern with significant implications for the patient’s families, direct care givers and society. Glymphatic system, which can be seen as a waste disposal system in the brain, has been implicated in neurodegenerative disorders. Critically, recently studies have also shown that glymphatic flow is affected by sleep. Hence, this minireview aims to elucidate the relationship between glymphatic system, sleep, and neurodegenerative disorders; as a basis for further research into possible preventive and/or early corrective measures for neurodegenerative disorders.

Keywords: Glymphatic System (GS); Cerebrospinal Fluid (CSF); Central Nerverous System (CNS); Alzheimer’s disease (AD); Parkinson’s disease (PD)

  1. Hablitz LM and Nedergaard M. “The glymphatic system: a novel component of fundamental neurobiology”. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience37 (2021): 7698-7711.
  2. Deng S., et al. “Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice”. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism9 (2024): 1515-1531.
  3. Ahadiat S-A and Hosseinian Z. “Astrocytes’ innate role in neurodegenerative disorders”. Bulletin of the National Research Centre1 (2023): 105.
  4. Mendelsohn AR and Larrick JW. “Sleep facilitates clearance of metabolites from the brain: glymphatic function in aging and neurodegenerative diseases”. Rejuvenation Research6 (2013): 518-523.
  5. Gan Y., et al. “Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism”. Journal of the Royal Society, Interface206 (2023): 20230288.
  6. Achariyar TM., et al. “Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation”. Molecular Neurodegeneration1 (2016): 74.
  7. Sriram S., et al. “Astrocyte regulation of extracellular space parameters across the sleep-wake cycle”. Frontiers in Cellular Neuroscience 18 (2024): 1401698.
  8. Demiral ŞB., et al. “Apparent diffusion coefficient changes in human brain during sleep - Does it inform on the existence of a glymphatic system?” NeuroImage 185 (2019): 263-273.
  9. Ahmadian N., et al. “Tau pathology of Alzheimer disease: Possible role of sleep deprivation”. Basic and Clinical Neuroscience5 (2018): 307-316.
  10. Wostyn P and Goddaer P. “Can immersive sound therapy counteract neurodegeneration by enhancing glymphatic clearance? Comment on Sachdeva et al. Effects of sound interventions on the permeability of the blood-brain barrier and meningeal lymphatic clearance. Brain Sci. 2022, 12, 742”. Brain Sciences1 (2023): 98.
  11. Salminen A. “Aryl hydrocarbon receptor impairs circadian regulation in Alzheimer’s disease: Potential impact on glymphatic system dysfunction”. The European Journal of Neuroscience2 (2024): 3901-3920.
  12. Rudilosso S., et al. “Perivascular and parenchymal brain fluid diffusivity in patients with a recent small subcortical infarct”. Neuroradiology3 (2025): 599-611.
  13. Naour AL., et al. “Do astrocytes respond to light, sound, or electrical stimulation?” Neural Regeneration Research 11 (2023): 2343-2347.
  14. Bèchet NB., et al. “Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system”. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism10 (2020): 1975-1986.
  15. Roy B., et al. “The role of the glymphatic system in perioperative neurocognitive disorders”. Journal of Neurosurgical Anesthesiology 2 (2025): 181-187.
  16. Xiong R., et al. “Evaluation of glymphatic system dysfunction in patients with insomnia via diffusion tensor image analysis along the perivascular space”. Quantitative Imaging in Medicine and Surgery2 (2025): 1114-1124.
  17. Sun X., et al. “40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice”. Cell Discovery1 (2024): 81.
  18. Cankar N., et al. “Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model”. Cell Reports 11 (2024): 114977.
  19. Kroeger D and Vetrivelan R. “To sleep or not to sleep - Effects on memory in normal aging and disease”. Aging Brain 3 (2023): 100068.
  20. Buongiorno M., et al. “Altered sleep and neurovascular dysfunction in alpha-synucleinopathies: the perfect storm for glymphatic failure”. Frontiers in Aging Neuroscience 15 (2023): 1251755.
  21. Scott-Massey A., et al. “Glymphatic system dysfunction and sleep disturbance may contribute to the pathogenesis and progression of Parkinson’s disease”. International Journal of Molecular Sciences 21 (2022): 12928.
  22. Kyriaki Astara., et al. “A novel conceptual framework for the functionality of the glymphatic system”. Journal of Neurophysiology5 (2023): 1228-1236.
  23. Ekanayake A., et al. “A review of the role of estrogens in olfaction, sleep and glymphatic functionality in relation to sex disparity in Alzheimer’s disease”. American Journal of Alzheimer’s Disease and Other Dementias 39 (2024): 15333175241272025.
  24. Kolmakova KA., et al. “Assessment of the significance of dilated perivascular spaces and nocture arterial hypertension in the development of Alzheimer’s disease”. Zhurnal Nevrologii I Psikhiatrii Imeni SS Korsakova4-2 (2024): 33-40.
  25. Ozdinler PH. “Sleep apnea and amyotrophic lateral sclerosis: cause, correlation, any relation?” Brain Sciences10 (2024): 978.
  26. Eisen A., et al. “The glymphatic system and amyotrophic lateral sclerosis”. Progress in Neurobiology 234 (2024): 102571.
  27. Liu S., et al. “Glymphatic dysfunction in patients with early-stage amyotrophic lateral sclerosis”. Brain: A Journal of Neurology 1 (2024): 100-108.
  28. Lang C. “Sleep alterations in amyotrophic lateral sclerosis”. Current Opinion in Neurology5 (2025): 606-613.
  29. Han F., et al. “Decoupling of global brain activity and cerebrospinal fluid flow in Parkinson’s disease cognitive decline”. Movement Disorders: Official Journal of the Movement Disorder Society9 (2021): 2066-2076.
  30. Lian X., et al. “Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson’s disease”. Neural Regeneration Research 1 (2026): 233-247.
  31. Shirolapov IV., et al. “The significance of glymphatic pathway in the relationship between the sleep-wake cycle and neurodegenerative diseases”. Zhurnal Nevrologii I Psikhiatrii Imeni SS Korsakova10 (2023): 42-47.
  32. Hicks AJ., et al. “Associations of enlarged perivascular spaces with brain lesions, brain age, and clinical outcomes in chronic traumatic brain injury”. Neurology1 (2023): e63-e73.
  33. Klostranec JM., et al. “Current concepts in intracranial interstitial fluid transport and the glymphatic system: part I-anatomy and physiology”. Radiology 3 (2021): 502-514.
  34. Shirolapov IV., et al. “The significance of the glymphatic pathway in the relationship between the sleep-wake cycle and neurodegenerative diseases”. Zhurnal Nevrologii I Psikhiatrii Imeni SS Korsakova9 (2023): 31-36.
  35. Si X-L., et al. “Different perivascular space burdens in idiopathic rapid eye movement sleep behavior disorder and Parkinson’s disease”. Frontiers in Aging Neuroscience 12 (2020): 580853.

Hee Boon Ng and Maurice HT Ling. “Relationship of Glymphatic System to Sleep and Neurodegenerative Disorders”. EC Clinical and Medical Case Reports 9.6 (2026): 01-05.

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