EC Clinical and Medical Case Reports

Appendiceal neoplasms are uncommon, occurring in 0.5 - 1.0% of appendectomy specimens submitted for histopathological examination, with an annual incidence of roughly 1.2 cases per 100,000 individuals in the United States. The main objective of this study was to present a rare case of non-mucinous appendiceal adenocarcinoma.

NMAC of the appendix is an uncommon and unique lesion that occurs. It may arise from a preexisting sessile serrated adenoma. Non-mucinous adenocarcinomas of the appendix are genetically altered differently, therapeutically respond differently and have different prognostic outcomes than MAC. It is important to accurately identify NMAC from MAC because of these differences for effective therapeutic measures and treatment prognosis. A definite diagnosis requires a clear and sufficient sample and morphological description and detailed histopathological examination of the appendix. So, being more aware in your clinical practice and standardizing the histopathological diagnosis could help in identifying and treating this rare cancer.

 Keywords: Non-Mucinous Appendiceal Adenocarcinoma (NMAC); Appendiceal Neoplasms; Sessile Serrated Adenoma; Histopathological Examination; Prognosis and Treatment

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