EC Clinical and Medical Case Reports

Lissencephaly, also known as "smooth brain," is a severe and rare malformation of the cerebral cortex. It is defined as a gyration anomaly, either complete (total absence of cortical sulci) known as agyria, or pachygyria if there are still some sulci present. This condition is most often secondary to an anomaly in neuronal migration during embryogenesis. It is frequently observed in developing countries and its management is complex and challenging. We report the case of a one-and-a-half-year-old female patient with no significant medical history, admitted to the emergency department for repeated convulsive seizures. Her primary care physician requested a brain MRI.

 Keywords: Lissencephaly; Gyration Anomaly; Pachygyria; MRI

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