EC Clinical and Medical Case Reports

Guest Editorial Volume 6 Issue 12 - 2023

Intermittent Fasting: A Trend or an Efficient Method to Lose Weight?

Carmine Finelli*

Department of Internal Medicine, ASL Napoli 3 Sud, Via di Marconi, Torre del Greco, Napoli, Italy.

*Corresponding Author: Carmine Finelli, Department of Internal Medicine, ASL Napoli 3 Sud, Via di Marconi, Torre del Greco, Napoli, Italy.
Received: November 06, 2023; Published: November 24, 2023



Introduction: Dietary fads that don’t seem to be going away anytime soon include intermittent fasting (IF) [1]. It’s when you voluntarily abstain from food and beverages other than water for a set amount of time. While some individuals fast for health-related reasons, others fast for spiritual reasons [2,3].

On overweight rats, numerous very promising research on IF have been carried out [4]. They experience a drop in their weight, blood pressure, cholesterol, and blood sugar. But they’re rats. IF has been shown to be safe and successful in nearly a dozen human studies, though not much more so than any other diet [5]. In addition, many people find it difficult to fast.

However, an increasing amount of evidence indicates that the timing of the fast is crucial and can help make IF a more practical, long- lasting, and successful strategy for both diabetes prevention and weight loss [6].

Weight loss can be aided by intermittent fasting: IF seems to make sense. Enzymes in our stomach break down the food we eat, resulting in chemicals entering our bloodstream [7]. Our cells swiftly convert carbohydrates-especially sugars and refined grains like rice and white flour-into sugar, which is what gives us energy [8]. We keep it in our fat cells as well, because our cells don’t use it completely up [9]. But insulin, a hormone produced in the pancreas, is necessary for sugar to enter our cells. Sugar enters and remains in fat cells thanks to insulin.

Several studies in humans comparing fasting every other day with eating less every day found that both had similar weight loss effects, even if people had difficulty tolerating fasting days [10-12]. So, choosing a low-calorie, plant-based, Mediterranean-style diet makes sense [13]. But research shows that not all IF approaches are created equal and that some IF diets are actually effective and sustainable, especially when combined with a nutrient-rich plant-based diet [14,15].

Disclosure Statement: The authors declare that there are no conflicts of interest.

  1. Collier R. “Intermittent fasting: the science of going without”. Canadian Medical Association Journal 185.9 (2013): E363-E364.
  2. Patterson RE., et al. “Intermittent fasting and human metabolic health”. Journal of the Academy of Nutrition and Dietetics 115.8 (2015): 1203-1212.
  3. Hoddy KK., et al. “Intermittent fasting and metabolic health: from religious fast to time-restricted feeding”. Obesity (Silver Spring) 28.1 (2020): S29-S37.
  4. Zang BY., et al. “Intermittent fasting: potential bridge of obesity and diabetes to health?” Nutrients 14.5 (2022): 981.
  5. Gabel K and Varady KA. “Current research: effect of time-restricted eating on weight and cardiometabolic health”. Journal of Physiology 600.6 (2022): 1313-1326.
  6. Ojo TK., et al. “Role of intermittent fasting in the management of prediabetes and type 2 diabetes mellitus”. Cureus 14.9 (2022): e28800.
  7. Patricia JJ and Dhamoon AS. “Physiology, Digestion”. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing (2023).
  8. Holesh JE., et al. “Physiology, Carbohydrates”. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing (2023).
  9. Chait A and den Hartigh LJ. “Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease”. Frontiers in Cardiovascular Medicine 7 (2020): 22.
  10. Gabel K., et al. “Differential effects of alternate-day fasting versus daily calorie restriction on insulin resistance”. Obesity (Silver Spring) 27.9 (2019): 1443-1450.
  11. Silva AI., et al. “Effects of intermittent fasting on regulation of metabolic homeostasis: a systematic review and meta-analysis in health and metabolic-related disorders”. Journal of Clinical Medicine 12.11 (2023): 3699.
  12. Sharma SK., et al. “Effect of intermittent fasting on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials”. touchREVIEWS in Endocrinology 19.1 (2023): 25-32.
  13. Figueroa C., et al. “Introducing plant-based Mediterranean diet as a lifestyle medicine approach in Latin America: opportunities within the Chilean context”. Frontiers in Nutrition 8 (2021): 680452.
  14. Kim JY. “Optimal diet strategies for weight loss and weight loss maintenance”. Journal of Obesity and Metabolic Syndrome 30.1 (2021): 20-31.
  15. Key TJ., et al. “Plant-based diets and long-term health: findings from the EPIC-Oxford study”. Proceedings of the Nutrition Society 81.2 (2022): 190-198.
  16. Meléndez-Fernández OH., et al. “Circadian rhythms disrupted by light at night and mistimed food intake alter hormonal rhythms and metabolism”. International Journal of Molecular Sciences 24.4 (2023): 3392.
  17. Liu D., et al. “Calorie restriction with or without time-restricted eating in weight loss”. New England Journal of Medicine 386.16 (2022): 1495-1504.
  18. Kokkinopoulou A., et al. “Does religious fasting have a protective role against metabolic syndrome in individuals aged >50 years?” Nutrients 15.14 (2023): 3215.
  19. Song DK and Kim YW. “Beneficial effects of intermittent fasting: a narrative review”. Journal of Yeungnam Medical Science 40.1 (2023): 4-11.
  20. Gu L., et al. “Effects of intermittent fasting in human compared to a non-intervention diet and caloric restriction: a meta-analysis of randomized controlled trials”. Frontiers in Nutrition 9 (2022): 871682.

Carmine Finelli., et al. “Intermittent Fasting: A Trend or an Efficient Method to Lose Weight?”. EC Clinical and Medical Case Reports 6.12 (2023): 01-04