EC Clinical and Medical Case Reports

Alice in Wonderland syndrome is a rare neuropsychiatric disease that refers to the visual distortions perceiving the altered one’s body image and other objects around them with disturbed sense of distance and time. It includes distortions of the size, mass or the patients own body shape often accompanied by depersonalization and derealization. Alice in Wonderland syndrome appears to have been associated with certain viral infections, epilepsy, migraine, intoxication and brain tumors. The purpose of this review is to provide an UpToDate knowledge about the Alice in Wonderland syndrome discussing the disease in various steps involving the history, clinical symptoms, causes, diagnosis and treatment in the light of recent researches carried out in the same field.

 Keywords: AIWS; Neuropsychiatric Disorder; Visual Distortions; Hallucinations; Abnormal Beliefs; Migraines; Tachysensia; Paranoia; Zoopsias

1. Farooq O and Fine EJ. “Alice in Wonderland syndrome: A historical and medical review”. Pediatric Neurology 77 (2017): 5-11.
2. Patrick O’Toole and Modestino EJ. “Alice in Wonderland syndrome: A real life version of Lewis Carroll’s novel”. Brain and Development 6 (2017): 470-474.
3. Lanska DJ., et al. “Alice in Wonderland syndrome”. Frontiers of Neurology and Neuroscience 42 (2018): 142-150.
4. Todd J. “The syndrome of Alice in Wonderland”. Canadian Medical Association Journal9 (1955): 701-704.
5. Green R and Cohen M. “Lewis Carroll correspondence”. Notes and Queries7 (1964): 271.
6. Drysdale GR. “Kaethe Kollwitz (1867-1945): the artist who may have suffered from Alice in Wonderland syndrome”. Journal of Medical Biography 2 (2009): 106-110.
7. Chirchiglia D., et al. “De Chirico and Alice in Wonderland syndrome: When neurology creates art”. Frontiers in Neurology 9 (2018): 553.
8. Ffytche DH. “Visual hallucinatory syndrome: Past, present and future”. Dialogues in Clinical Neuroscience 2 (2007): 173-189.
9. Weissenstein A., et al. “Alice in Wonderland syndrome: A rare neurological manifestation with microscopy in a 6-year-old Child”. Journal of Pediatric Neurosciences 3 (2014): 303-304.
10. Blom JD. “Alice in Wonderland syndrome”. Neurology: Clinical Practice3 (2016): 259-270.
11. Mastria G., et al. “Alice in Wonderland syndrome: A clinical and pathophysiological review”. BioMed Research International (2016): 8243145.
12. Blom JD., et al. “Time distortions: A systematic review of cases characteristic of Alice in Wonderland syndrome”. Frontiers in Psychiatry 12 (2021): 668633.
13. Luis PG., et al. “Infectious causes of Alice in Wonderland syndrome”. Journal of NeuroVirology4 (2021): 550-556.
14. Eshel L. “Alice in Wonderland syndrome: A manifestation of infectious mononucleosis in children”. Behavioral Neurology 3 (1991): 163-166.
15. Cinbis M and Aysun S. “Alice in Wonderland syndrome as an initial manifestation of Epstein-Barr virus infection”. British Journal of Ophthalmology 5 (1992): 316.
16. Feldman C. “A Not So Pleasant Fairy Tale: Investigating Alice in Wonderland syndrome”. Serendip. Serendip Studio, Bryn Mawr College (2011).
17. Jurgens TP., et al. “Alice in Wonderland syndrome associated with topiramate for migraine prevention”. Journal of Neurology, Neurosurgery and Psychiatry2 (2011): 228-229.
18. Hanson D. “Eye on Fiction: Heavenly and hellish-writers on hallucinogens”. The Psychologist9 (2014): 680.
19. Liu AM., et al. “Alice in Wonderland syndrome: Presenting and follow-up characteristics”. Pediatric Neurology3 (2014): 317-320.
20. Paniz-Mondolfi AE., et al. “Alice in Wonderland syndrome: A novel neurological presentation of Zika virus infection”. Journal of NeuroVirology5 (2018): 660-663.
21. Brroks JBB., et al. “Alice in Wonderland syndrome: Who in the world am I?” Arquivos de Neuro-Psiquiatria9 (2019): 672-674.
22. Tirza N., et al. “Alice in Wonderland syndrome as a presenting manifestation of Creutzfeldt-Jacob disease”. Frontiers in Neurology 10 (2019): 473.
23. Kubota K., et al. “Alice in Wonderland syndrome associated with influenza virus infection”. Pediatric International12 (2020): 1391-1393.
24. Vilela M., et al. “When Alice took sertraline: A case of sertraline-induced Alice in Wonderland syndrome”. Cureus 8 (2020): e10140.