EC Clinical and Medical Case Reports

Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant genetic disorder that features multiples mucocutaneous pigmentation, hamartomatous polyps usually in the small intestine, and often a family history of the condition. These polyps can lead to intermittent abdominal pain, chronic anemia, and, notably, bowel obstruction due to intussusception, where a segment of the intestine folds into itself. Patients suffering from this syndrome have an increased risk for common and unusual types of gastrointestinal and non-gastrointestinal tumors. Recent guidelines recommend regular small-bowel surveillance to reduce these risks associated with PJS. Imaging techniques such as CT scans are valuable in detecting intussusception caused by these polyps. However, a definitive diagnosis of Peutz-Jeghers Syndrome requires histological examination of the polyps. we present a rare case of a 17-year-old female with chronic anemia and abdominal pain, where double intussusception was identified on CT scans. Subsequent surgical resection of the polyps revealed the presence of hamartomatous Peutz-Jeghers polyps upon histological examination.

 Keywords: Peutz-Jeghers Syndrome (PJS); Intussusception; Polyps

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