EC Clinical and Medical Case Reports

Multiple myeloma is a malignant hematologic disorder characterized by the clonal proliferation of plasma cells in the bone marrow. These abnormal plasma cells produce excessive amounts of monoclonal immunoglobulin, leading to various complications such as bone lesions. Imaging plays a crucial role in the diagnosis, especially in the presence of bone pain. Techniques such as X-rays, MRI, and CT scans are essential for detecting lytic lesions, bone fractures, and other skeletal abnormalities associated with the disease. We present the case of a patient admitted with dorsolumbar pain for the past month, accompanied by weight loss. CT and MRI revealed bone lesions which, in conjunction with the biological abnormalities, are suggestive of multiple myeloma.

 Keywords: Multiple Myeloma; Kahler's Disease; Monoclonal Gammopathies; Medullary Plasmacytosis

1. Palumbo A and Anderson K. “Multiple myeloma”. New England Journal of Medicine 364 (2011): 1046-1060.
2. Facon T., et al. “Myélome multiple”. EMC Hématologie, 13-014-E-10 (2003): 15.
3. Manier S., et al. “Myélome multiple: des critères diagnostiques et pronostiques renouvelés et de forts espoirs thérapeutiques”. La Presse Médicale 7-8 (2019): 825-831.
4. Touzeau C and Moreau P. “Imagerie du myélome multiple”. Journal de Radiologie Diagnostique et Interventionnelle2 (2013): 196-198.
5. Lodé L., et al. “Facteurs pronostiques biologiques dans le myélome multiple”. Hématologie5 (2005): 346-350.
6. Bladé J and Rosinol L. “Renal hematologic and infectious complications in multiple myeloma”. Best Practice and Research Clinical Haematology 4 (2005): 635-652.
7. Rajkumar SV., et al. “International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma”. Lancet Oncology12 (2014): e538-e548.
8. Bouatay A., et al. “Myélome multiple: aspect clinique, diagnostic biologique et prognostic”. Immuno-Analyse & Biologie Spécialisée1 (2013): 30-35.
9. Touzeau C and Moreau P. “Imagerie du myélome multiple”. Journal de Radiologie Diagnostique et Interventionnelle2 (2013): 196-198.
10. Moulopoulos LA., et al. “Prognostic significance of magnetic resonance imaging of bone marrow in previously untreated patients with multiple myeloma”. Annals of Oncology 11 (2005): 1824-1828.