EC Clinical and Medical Case Reports

Review Article Volume 6 Issue 5 - 2023

Butyric Acid Fermented in Aloe Vera Gel Exerts an Anti-Tumor Effect as a Histone Deacetylase Inhibitor and an Immune Checkpoint Inhibitor Case Reports: Mitigation of Cervical Cancer and a Small Cerebral Neoplasm with Aloe Vera Juice as an Adjuvant

Akira Yagi1*, Megumi Hasegawa2 and Kosuke Shiba3

1Special Advisor of Japan Aloe Science Association, Professor Emeritus, Fukuyama University, Hiroshima, Japan

2Pharmacist, Kampo Pharmacy, Grace-Meg-Salon, Toshima-Ku, Tokyo, Japan

3A Clinical Director of Medical Association and Occupational Physician, Yokohama City, Kanagawa-ken, Japan

*Corresponding Author: Akira Yagi, Special Advisor of Japan Aloe Science Association, Professor Emeritus, Fukuyama University, Hiroshima, Japan.
Received: April 10, 2023; Published: April 21, 2023



As one of histone deacetylase inhibitors, butyrate may be overcome by several approaches with anti-multiple myeloma agents and as an adjuvant. Butyrate may mediate its anti-cancer effects as a potential therapeutic prodrug for multiple-myeloma cells apoptosis, partly through microRNA (miRNA) or in collaboration with miRNA. Butyrate fermented in aloe vera gel exerts an anti-tumor effect as a histone deacetylase inhibitor and as an immune checkpoint inhibitor. Case report 1, 2 and 3 showed that the long-time ingestion of aloe vera juice possibly mitigated cervical cancer and a small cerebral neoplasm as an adjuvant.

Keywords: Butyric Acid; Aloe Vera; Histone Deacetylase Inhibitor; Cervical Cancer; Cerebral Neoplasm

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Akira Yagi., et al. "Butyric Acid Fermented in Aloe Vera Gel Exerts an Anti-Tumor Effect as a Histone Deacetylase Inhibitor and an Immune Checkpoint Inhibitor Case Reports: Mitigation of Cervical Cancer and a Small Cerebral Neoplasm with Aloe Vera Juice as an Adjuvant." EC Clinical and Medical Case Reports   6.5 (2023): 11-17.