EC Clinical and Medical Case Reports

Review Article Volume 8 Issue 6 - 2025

Bio-Stimulant Effects of the Fermentation Extract by Endophytic Microbiota from Outer Leaf Layer in Aloe Vera

Akira Yagi1* and Karen AM Koch2

1Special Adviser of Japan Aloe Science Association, Emeritus Professor of Fukuyama University in Hiroshima, Japan

2President of Aloe Life International, USA

*Corresponding Author: Akira Yagi, Special Adviser of Japan Aloe Science Association, Emeritus Professor of Fukuyama University in Hiroshima, Japan.
Received: April 25, 2025; Published: May 20, 2025




The acidic solution from the fermented Aloe vera outer layer is applied as an organic Aloe booster for agricultural field.

 Keywords: Bio-Stimulant; Fermentation; Endophytic Microbiota; Aloe vera

  1. H Kaneko., et al. “Diversity and characteristics of plant immunity-activating bacteria from Brassicaceae plants”. BMC Microbiology1 (2023): 175.
  2. Missa M., et al. “Isolation and antibacterial test of Aloe vera endophytic bacteria towards Staphylococcus aureus and Escherichia coli bacteria”. Agro-bali Agricultural Journal 1 (2023): 196-208.
  3. A Yagi., et al. “Short-chain fatty acids from fermentation by endophytic bacteria in Aloe vera leaf rind and gel”. Journal of Gastroenterology and Hepatology Research 4 (2016): 658.
  4. L Al-Madboly., et al. “Dietary Aloe vera gel juice on growth of Lactobacillus fermentum and helveticus isolates in vitro”. Journal of Gastroenterology and Hepatology Research 6.3 (2017): 2365-2369.
  5. K Zhang., et al. “Effect of Lactobacillus helveticus: oxo-polysaccharides. Molecular weight yogurt on gel properties and its intestinal mechanism”. International Journal of Biological Macromolecules 1 (2024): 130006.
  6. DP Bartel., et al. “MicroRNAs: target recognition and regulating function”. Cell (Review)2 (2009): 215-233.
  7. H Iwaikawa and Y Tomari. “Molecular insights into micRNA-mediated translational repression in plants”. Molecular Cell 4 (2013): 591-601.
  8. JA Chebaneva and DA Belostotsky. “MicroRNA and messenger RNA turnover”. Methods in Molecular Biology 342 (2006): 73-85.
  9. N Takayanagi and M Otani. “Characteristic and physiological properties of pre-microRNA splicing in plants”. Journal of Japanese Biochemical Society 6 (2022): 861-867.
  10. NJ Sadynove., et al. “Pharmacodynamics of Aloe vera and acemannan in therapeutic applications for skin, digestion and immunomodulation”. Phytotherapy Research 12 (2021): 6572-6484.
  11. A Yagi., et al. “Immune modulation by acemannan and fermented butyrate for cursing on macrophages and micRNA regulation, and Case reports with Aloe supplement”. Journal of Gastroenterology and Hepatology Research 3 (2020): 3158-3163.
  12. H Miyagi., et al. “Possible prophylaxes of Aloe vera gel to micRNA regulation and questionnaire”. EC Clinical and Medical Case Reports8 (2020): 79-81.
  13. A Yagi., et al. “Isolation and characterization of the glycoprotein fraction and characterization of the glycoprotein fraction with a proliferation-promoting activity on human and Hamster cells in vitro from Aloe vera gel”. Planta Medica1 (1997): 18-21.
  14. MK Kim., et al. “The antioxidant effect of small extracellular vesicles derived from Aloe vera peels for wound healing”. Tissue Engineering 4 (2021): 561-571.
  15. E Carzoni., et al. “Aloe extracellular vesicles as carriers of photoinducible metabolites exhibiting cellular phototoxicity”. Cells22 (2024): 1845.
  16. H Zhou., et al. “Aloe-derived vesicles enable macrophage reprogram regulate the inflammatory immune environment”. Frontiers in Bioengineering and Biotechnology 11 (2023): 1339941.
  17. J Pengnet., et al. “SNHG1/micR-21 axis mediates the cardioprotective role of aloin in sepsis through modulating cardiac cell viability”. Journal of Clinical Laboratory Analysis 21-22 (2023): e24985.
  18. J Xie., et al. “Roles of microRNA-21 in skin wound healing: A comprehensive review”. Frontiers in Pharmacology 13 (2022): 828627.
  19. FDC Costa., et al. “Aloe vera increases mRNA expression of antioxidant enzymes in cryo-preserved bovine ovarian tissue and promotes follicular growth and survival after in vitro culture”. Cryobiology 102 (2021): 104-113.
  20. Vanancia A., et al. “Effect of Aloe vera extract on growth, viability, ultra-structure and expression of mRNA for antioxidant enzymes in bovine secondary follicles cultured in vitro”. Animal Reproduction Science 247 (2022): 107078.
  21. A Yagi., et al. “Application of the fermented extract of Aloe vera leaf dry-crushed powders for agricultural behind the concept of DR, Montogomery and A, Bickle; The hidden half of Nature, The microbial roots of Life and Health and Microbiome Agriculture Beyond on Organic Farming, Case report 1: Efficacy of endophytically fermented extract from twelve crude drugs of Kampo as an official plant roots growing regulation(ALM green) in Japan, Case report 2: Application of the fermented Aloe vera dry-rind powders and ALM green in circulation-type agriculture, and Case report 3: Prophylactic role of Aloe vera whole leaf extracted, certified by International Aloe Science Council as the purified leaf extract”. EC Clinical and Medical Care Reports1 (2024): 01-011.

Akira Yagi and Karen AM Koch. "Bio-Stimulant Effects of the Fermentation Extract by Endophytic Microbiota from Outer Leaf Layer in Aloe Vera ." EC Clinical and Medical Case Reports 8.6 (2025): 01-05.

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