EC Clinical and Medical Case Reports

Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. PRCA is a rare disorder that can affect any age and both genders equally. PRCA may be congenital or acquired. Diamond-Blackfan anemia is a congenital form of PRCA. Herein, we present a series of three cases of pure red cell aplasia presenting with unusual clinical and other rare haematological findings. PRCA is a rare disorder with varied etiology, where no cause can be established, it is labelled as idiopathic PRCA, treatment is done with corticosteroids (first line of therapy), which show a response by 4 weeks. Any anaemia of prolonged duration, not responding to conventional therapy should be evaluated by bone marrow studies to rule out ineffective erythropoiesis, dysplastic syndromes, infiltrative diseases of the bone marrow or a selective erythroid suppression.

Keywords: Anaemia; Idiopathic; PRCA

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